Levy Jason A, Marchand Melissa, Iorio Leanne, Zribi Gilles, Zahalsky Michael P
J Am Osteopath Assoc. 2015 Oct;115(10):e8-13. doi: 10.7556/jaoa.2015.124.
Peyronie disease (PD) is a connective tissue disorder involving the formation of fibrous plaques in the tunica albuginea. Abnormal plaques and scar tissue create a chronic state of inflammation, causing increased curvature of the penis as well as erectile dysfunction.
To determine the feasibility and effects of using placental matrix-derived mesenchymal stem cells (PM-MSCs) in the management of PD.
In a prospective study, patients with PD were injected with PM-MSCs, and followed up at 6-week, 3-month, and 6-month intervals to assess changes in plaque volume, penile curvature, and erectile function status (measured using peak systolic velocity, end-diastolic velocity, and the International Index of Erectile Function questionnaire).
In the 5 patients enrolled in the study, statistically significant increases in peak systolic velocity occurred after PM-MSC injection (P<.01). Of a total of 10 plaques managed, 7 had disappeared completely at 3-month follow-up. Changes in end-diastolic velocity, stretched penile length, and penile girth were not statistically significant.
To our knowledge, this study is the first on the use of stem cells to manage PD in humans. The results suggest that PM-MSCs may be beneficial and effective as a nonsurgical treatment in patients with PD. Future studies with long-term follow-up in a larger sample of patients are warranted. (ClinicalTrials.gov number NCT02395029).
佩罗尼氏病（PD）是一种结缔组织疾病，涉及白膜中纤维斑块的形成。异常斑块和瘢痕组织会引发慢性炎症状态，导致阴茎弯曲增加以及勃起功能障碍。
确定使用胎盘基质来源的间充质干细胞（PM-MSCs）治疗佩罗尼氏病的可行性和效果。
在一项前瞻性研究中，对佩罗尼氏病患者注射PM-MSCs，并在6周、3个月和6个月的间隔时间进行随访，以评估斑块体积、阴茎弯曲度和勃起功能状态的变化（使用收缩期峰值流速、舒张末期流速和国际勃起功能指数问卷进行测量）。
在该研究纳入的5名患者中，注射PM-MSCs后收缩期峰值流速有统计学意义的增加（P<0.01）。在总共治疗的10个斑块中，7个在3个月随访时完全消失。舒张末期流速、阴茎拉伸长度和阴茎周长的变化无统计学意义。
据我们所知，本研究是首次关于使用干细胞治疗人类佩罗尼氏病的研究。结果表明，PM-MSCs作为佩罗尼氏病患者的非手术治疗可能是有益且有效的。有必要在更大样本的患者中进行长期随访的未来研究。（ClinicalTrials.gov编号NCT02395029）
