Achraf Chatar, Abdelghani Pr Ammani, Jihad Pr El Anzaoui
Urology department, CHU Hassan II, Fes, Morocco.
Military Hospital Moulay Ismail, Meknes, Morocco.
Arab J Urol. 2022 Oct 25;21(2):69-75. doi: 10.1080/2090598X.2022.2135284. eCollection 2023.
The objective of our study is to discover and evaluate the effects of repeated intralesional injections inside the tunica albuginea of platelet-rich plasma (PRP) in the treatment of Peyronie's disease (PD).
As part of a prospective study over 12 months from February 2020 until February 2021, on Sixty-five patients with Peyronie's disease, and penile curvature between 25 and 45°. Patients were stratified into two groups, the first with a curvature between 25 and 35° and the second between 35 and 45°. Gathered data included patient-demographics, Injection technique, outcomes: both quantitative (curvature assessments) and qualitative (state of erectile function, pain during intercourse), and complications.
Patients in both groups received an average of 6.1 injections of PRP during the study period. Angulation was significantly improved in both groups an average final improvement of 16.88° (SD = 3.35) (p < 0.001) in the first group and 17.27° (SD = 4.22) (p < 0.001) in the second group. Pain during sex decreased from 70.7% to 34.25%, and 55.5% of patients had easier sexual intercourse.
The positive results of our series of treatment for Peyronie's disease by injection of platelet-rich plasma are encouraging both methodologically (simplicity) and clinical (safety and efficacy) as well as patient satisfaction.
我们研究的目的是发现并评估在白膜内重复注射富血小板血浆（PRP）治疗佩罗尼氏病（PD）的效果。
作为一项前瞻性研究的一部分，从2020年2月至2021年2月历时12个月，研究对象为65例佩罗尼氏病患者，阴茎弯曲度在25至45°之间。患者被分为两组，第一组弯曲度在25至35°之间，第二组在35至45°之间。收集的数据包括患者人口统计学信息、注射技术、结果：包括定量（弯曲度评估）和定性（勃起功能状态、性交时疼痛）以及并发症。
在研究期间，两组患者平均接受了6.1次PRP注射。两组的角度均有显著改善，第一组平均最终改善16.88°（标准差=3.35）（p<0.001），第二组平均最终改善17.27°（标准差=4.22）（p<0.001）。性交时疼痛从70.7%降至34.25%，55.5%的患者性交变得更容易。
我们通过注射富血小板血浆治疗佩罗尼氏病的系列治疗结果在方法学上（简单性）、临床方面（安全性和有效性）以及患者满意度方面都令人鼓舞。
