Kerley Conor P, Hutchinson Katrina, Bolger Kenneth, McGowan Aisling, Faul John, Cormican Liam
Respiratory and Sleep Diagnostics Department, Connolly Hospital, Blanchardstown, Dublin, Ireland.
School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland.
Sleep. 2016 Feb 1;39(2):293-300. doi: 10.5665/sleep.5430.
To evaluate vitamin D (25(OH)D) levels in obstructive sleep apnea syndrome (OSAS) and possible relationships to OSAS severity, sleepiness, lung function, nocturnal heart rate (HR), and body composition. We also aimed to compare the 25(OH)D status of a subset of OSAS patients compared to controls matched for important determinants of both OSAS and vitamin D deficiency (VDD).
This was a cross-sectional study conducted at an urban, clinical sleep medicine outpatient center. We recruited newly diagnosed, Caucasian adults who had recently undergone nocturnal polysomnography. We compared body mass index (BMI), body composition (bioelectrical impedance analysis), neck circumference, sleepiness (Epworth Sleepiness Scale), lung function, and vitamin D status (serum 25-hydrpoxyvitamin D (25(OH)D) across OSAS severity categories and non-OSAS subjects. Next, using a case-control design, we compared measures of serum 25(OH)D from OSAS cases to non-OSAS controls who were matched for age, gender, skin pigmentation, sleepiness, season, and BMI.
106 adults (77 male; median age = 54.5; median BMI = 34.3 kg/m(2)) resident in Dublin, Ireland (latitude 53°N) were recruited and categorized as non-OSAS or mild/moderate/severe OSAS. 98% of OSAS cases had insufficient 25(OH)D (< 75 nmol/L), including 72% with VDD (< 50 nmol/L). 25(OH)D levels decreased with OSAS severity (P = 0.003). 25(OH)D was inversely correlated with BMI, percent body fat, AHI, and nocturnal HR. Subsequent multivariate regression analysis revealed that 25(OH)D was independently associated with both AHI (P = 0.016) and nocturnal HR (P = 0.0419). Our separate case-control study revealed that 25(OH)D was significantly lower in OSAS cases than matched, non-OSAS subjects (P = 0.001).
We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. We provide evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.
评估阻塞性睡眠呼吸暂停综合征（OSAS）患者的维生素D（25（OH）D）水平，以及其与OSAS严重程度、嗜睡程度、肺功能、夜间心率（HR）和身体成分之间的可能关系。我们还旨在比较一部分OSAS患者与因OSAS和维生素D缺乏（VDD）的重要决定因素相匹配的对照组的25（OH）D状态。
这是一项在城市临床睡眠医学门诊中心进行的横断面研究。我们招募了最近接受夜间多导睡眠图检查的新诊断的白种成年人。我们比较了不同OSAS严重程度类别和非OSAS受试者的体重指数（BMI）、身体成分（生物电阻抗分析）、颈围、嗜睡程度（爱泼沃斯嗜睡量表）、肺功能和维生素D状态（血清25-羟基维生素D（25（OH）D））。接下来，采用病例对照设计，我们比较了OSAS病例与年龄、性别、皮肤色素沉着、嗜睡程度、季节和BMI相匹配的非OSAS对照组的血清25（OH）D水平。
招募了106名居住在爱尔兰都柏林（北纬53°）的成年人（77名男性；中位年龄 = 54.5岁；中位BMI = 34.3 kg/m²），并将其分类为非OSAS或轻度/中度/重度OSAS。98%的OSAS病例25（OH）D水平不足（< 75 nmol/L），其中72%患有VDD（< 50 nmol/L）。25（OH）D水平随OSAS严重程度的增加而降低（P = 0.003）。25（OH）D与BMI、体脂百分比、呼吸暂停低通气指数（AHI）和夜间心率呈负相关。随后的多变量回归分析显示，25（OH）D与AHI（P = 0.
