阻塞性睡眠呼吸暂停综合征患者的代谢综合征与维生素D水平
Metabolic Syndrome and Vitamin D Levels in Patients with Obstructive Sleep Apnea Syndrome.
作者信息
Archontogeorgis Kostas, Nena Evangelia, Papanas Nikolaos, Rizzo Manfredi, Voulgaris Athanasios, Xanthoudaki Maria, Kouratzi Maria, Ragia Georgia, Manolopoulos Vangelis, Zissimopoulos Athanasios, Froudarakis Marios, Steiropoulos Paschalis
机构信息
1 MSc Programme in Sleep Medicine, Medical School, Democritus University of Thrace , Alexandroupolis, Greece .
2 Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace , Alexandroupolis, Greece .
出版信息
Metab Syndr Relat Disord. 2018 May;16(4):190-196. doi: 10.1089/met.2017.0181. Epub 2018 Apr 2.
BACKGROUND
Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients.
METHODS
The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS.
RESULTS
A total of 107 subjects (88 men) with OSAS were included in the study. Patients were divided into group A (OSAS with MetS group: 55 subjects) and group B (OSAS without MetS: 52 subjects). There were no differences between the two groups in terms of age, body mass index, and sleep parameters. Patients in group A exhibited higher levels of daytime sleepiness, as expressed by Epworth Sleepiness Scale score (12 ± 5.5 vs. 9.3 ± 4.8 for groups A vs. B, p = 0.008). Serum 25(OH)D levels were significantly decreased in group A, as compared with group B (18 ± 8.6 ng/mL vs. 23.9 ± 14.1 ng/mL, respectively, p = 0.012). Group A was then subdivided in two smaller groups, according to patients' metabolic index: OSAS patients with metabolic score = 3 and OSAS patients with metabolic score >3. Serum 25(OH)D levels were higher in OSAS patients with metabolic score = 3 compared with OSAS patients with metabolic score >3 (19.8 ± 8.9 ng/mL vs. 15.1 ± 7.3 ng/mL respectively, p = 0.038).
CONCLUSIONS
OSAS patients with concurrent MetS exhibit lower serum Vit D levels, as compared with those without MetS.
背景
大量研究表明，阻塞性睡眠呼吸暂停综合征（OSAS）可能会促使代谢综合征（MetS）和糖尿病的发展。此外，OSAS与维生素D（Vit D）水平降低有关，但相关报道尚无定论。本研究的目的是比较OSAS患者中根据是否存在MetS及其组成成分的Vit D水平。
方法
对连续新诊断的经多导睡眠图检查的OSAS受试者评估是否存在MetS，并测量血清25-羟基维生素D [25(OH)D]水平。
结果
本研究共纳入107例OSAS受试者（88例男性）。患者分为A组（伴有MetS的OSAS组：55例受试者）和B组（不伴有MetS的OSAS组：52例受试者）。两组在年龄、体重指数和睡眠参数方面无差异。A组患者的日间嗜睡程度更高，用Epworth嗜睡量表评分表示（A组与B组分别为12±5.5 vs. 9.3±4.8，p = 0.008）。与B组相比，A组血清25(OH)D水平显著降低（分别为18±8.6 ng/mL vs. 23.9±14.1 ng/mL，p = 0.012）。然后根据患者的代谢指数将A组再细分为两个较小的组：代谢评分=3的OSAS患者和代谢评分>3的OSAS患者。代谢评分=3的OSAS患者的血清25(OH)D水平高于代谢评分>3的OSAS患者（分别为19.8±8.9 ng/mL vs. 15.1±7.3 ng/mL，p = 0.038）。
结论
与不伴有MetS的OSAS患者相比，并发MetS的OSAS患者血清Vit D水平较低。
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