Dixon Adam J, Kilroy Joseph P, Dhanaliwala Ali H, Chen Johnny L, Phillips Linsey C, Ragosta Michael, Klibanov Alexander L, Wamhoff Brian R, Hossack John A
IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Sep;62(9):1674-85. doi: 10.1109/TUFFC.2015.007143.
Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents.
血管内超声（IVUS）可提供无辐射的实时成像，并能从解剖学、功能和分子组成方面对动脉粥样硬化疾病进行评估。IVUS成像的主要临床应用包括评估管腔斑块体积以及为支架置入提供实时图像引导。当与微泡造影剂结合使用时，IVUS技术可扩展用于提供非线性成像、分子成像和治疗性给药模式。在本综述中，我们将讨论由IVUS成像技术和微泡造影剂相结合所实现的新兴成像和治疗应用的发展情况。
