Bakács T, Ringwald G, Kimber I
National Institute of Oncology, Budapest, Hungary.
J Clin Lab Immunol. 1989 Oct;30(2):61-7.
The influence of the concentration of membrane-bound antibody on the susceptibility of individual human erythrocyte populations to complement-mediated haemolysis has been examined using cold competition analysis. It was observed that under conditions where complement is limiting, the relative susceptibility of erythrocytes to complement lysis is dependent on the availability of sensitizing antibody, even when all target red cells possess sufficient membrane antibody to permit maximal lysis in the presence of excess complement. Furthermore, preliminary evidence is presented which suggests that, where the availability of complement is limiting, sensitized blood group A erythrocytes are more susceptible to complement lysis than are sensitized group B cells. Taken together the data indicate that the quantity, and possibly the distribution, of the membrane antibody dictates the relative susceptibility of erythrocytes to complement haemolysis.
利用冷竞争分析研究了膜结合抗体浓度对个体人类红细胞群体补体介导溶血易感性的影响。观察到在补体有限的条件下，红细胞对补体裂解的相对易感性取决于致敏抗体的可用性，即使所有靶红细胞都拥有足够的膜抗体，在补体过量时也能实现最大程度的裂解。此外，还提供了初步证据表明，在补体可用性有限的情况下，致敏的A型血型红细胞比致敏的B型细胞更容易受到补体裂解。综合这些数据表明，膜抗体的数量以及可能的分布决定了红细胞对补体溶血的相对易感性。
