Foster J A, Barnhorst D, Papay F, Oh P M, Wulc A E
Division of Ophthalmology, The Cleveland Clinic Foundation, OH 44195, USA.
Ophthalmology. 1996 Apr;103(4):618-22. doi: 10.1016/s0161-6420(96)30644-1.
External photography and subjective response were used to evaluate the use of botulinum A toxin to diminish glabellar kinetic folds.
Eleven patients with glabellar folds and midline forehead wrinkling received one to four injections of 0.1 ml of 100 U/1 ml botulinum A toxin. The injections were given into the procerus or corrugator muscles or both. The number of injections corresponded to the wrinkle lines in each patient. The patients were examined and photographed just before the injections and at 7 to 10 days after the injections. Treatment efficacy was judged by photographic evaluation and by the patient's subjective evaluation of the effect of the treatment.
Photographic evaluation showed objective improvement in the glabellar wrinkling in 6 of 11 patients in relaxed facial position and in all 11 patients during contraction of the periocular mulscles. Ten of the 11 patients reported satisfaction with their cosmetic results and indicated that they would choose to have the procedure done again.
The results of this study suggest that botulinum A toxin is a safe and effective treatment for glabellar folds.
采用外部摄影及主观反应来评估A型肉毒毒素减少眉间动态皱纹的效果。
11例有眉间皱纹及前额中线皱纹的患者接受了1至4次注射，每次注射0.1 ml的100 U/1 ml A型肉毒毒素。注射部位为降眉间肌或皱眉肌或两者。注射次数与每位患者的皱纹线数量相对应。在注射前及注射后7至10天对患者进行检查及拍照。通过摄影评估及患者对治疗效果的主观评估来判断治疗效果。
摄影评估显示，11例患者中，6例在面部放松位置时眉间皱纹有客观改善，11例患者在眼周肌肉收缩时眉间皱纹均有改善。11例患者中有10例对美容效果表示满意，并表示会选择再次接受该治疗。
本研究结果表明，A型肉毒毒素是治疗眉间皱纹的一种安全有效的方法。
