血管内皮生长因子（VEGF）基因+405G/C多态性与乳腺癌风险之间无关联：一项荟萃分析。

Lack of association between +405 G/C polymorphism in VEGF and breast cancer risk: A meta-analysis.

作者信息

Zhang Meng, Wu Xun, Wang Xiang, Zhang Duo, Wang Yongqiang, Lu Wei, Cai Zhiming, Wu Song

机构信息

Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen Guangdong, China.

出版信息

J BUON. 2015 Jul-Aug;20(4):970-7.

PMID:26416045

Abstract

PURPOSE

To explore whether the vascular endothelial growth factor (VEGF) +405 G/C polymorphism confers susceptibility to breast cancer (BC) by conducting a meta-analysis.

METHODS

Publications addressing the association between the VEGF +405 G/C polymorphism and BC risk were selected from the PubMed, Embase and Google Scholar databases. Data were extracted from studies by three independent reviewers. The meta-analysis was performed by STATA 12.0 software, and odds ratio (OR) with 95% confidence interval (CI) were calculated.

RESULTS

Finally, 10 case-control studies were retrieved with a total of 8,855 BC patients and 9,393 controls. No significant association was identified between VEGF +405 G/C polymorphism and BC risk in overall populations under 5 models (C vs G: OR=1.001, 95% CI=0.896-1.119, p=0.987; CC vs GG: OR=1.006, 95% CI=0.853-1.186, p=0.997; CG vs GG: OR= 0.985, 95% CI=0.823-1.178, p=0.779; CC vs CGs/GG: OR=1.019, 95% CI=0.921-1.127, p=0.722; CC/CG vs GG: OR=0.985, 95% CI=0.835-1.162, p=0.862), and also in the subgroup analysis by ethnicity.

CONCLUSION

Our study confirms that there is a lack of association between the VEGF +405 G/C polymorphism and BC risk.

摘要

目的

通过进行一项荟萃分析，探讨血管内皮生长因子（VEGF）+405 G/C多态性是否与乳腺癌（BC）易感性相关。

方法

从PubMed、Embase和谷歌学术数据库中筛选关于VEGF +405 G/C多态性与BC风险关联的出版物。由三位独立评审员从研究中提取数据。使用STATA 12.0软件进行荟萃分析，并计算比值比（OR）及95%置信区间（CI）。

结果

最终检索到10项病例对照研究，共纳入8855例BC患者和9393例对照。在5种模型下，总体人群中VEGF +405 G/C多态性与BC风险之间未发现显著关联（C vs G：OR = 1.001，95% CI = 0.896 - 1.119，p = 0.987；CC vs GG：OR = 1.006，95% CI = 0.853 - 1.186，p = 0.997；CG vs GG：OR = 0.985，95% CI = 0.823 - 1.178，p = 0.779；CC vs CGs/GG：OR = 1.019，95% CI = 0.921 - 1.127，p = 0.722；CC/CG vs GG：OR = 0.985，95% CI = 0.835 - 1.162，p = 0.862），按种族进行的亚组分析结果亦是如此。