Zhang Meng, Wu Xun, Wang Xiang, Zhang Duo, Wang Yongqiang, Lu Wei, Cai Zhiming, Wu Song
Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen Guangdong, China.
J BUON. 2015 Jul-Aug;20(4):970-7.
To explore whether the vascular endothelial growth factor (VEGF) +405 G/C polymorphism confers susceptibility to breast cancer (BC) by conducting a meta-analysis.
Publications addressing the association between the VEGF +405 G/C polymorphism and BC risk were selected from the PubMed, Embase and Google Scholar databases. Data were extracted from studies by three independent reviewers. The meta-analysis was performed by STATA 12.0 software, and odds ratio (OR) with 95% confidence interval (CI) were calculated.
Finally, 10 case-control studies were retrieved with a total of 8,855 BC patients and 9,393 controls. No significant association was identified between VEGF +405 G/C polymorphism and BC risk in overall populations under 5 models (C vs G: OR=1.001, 95% CI=0.896-1.119, p=0.987; CC vs GG: OR=1.006, 95% CI=0.853-1.186, p=0.997; CG vs GG: OR= 0.985, 95% CI=0.823-1.178, p=0.779; CC vs CGs/GG: OR=1.019, 95% CI=0.921-1.127, p=0.722; CC/CG vs GG: OR=0.985, 95% CI=0.835-1.162, p=0.862), and also in the subgroup analysis by ethnicity.
Our study confirms that there is a lack of association between the VEGF +405 G/C polymorphism and BC risk.
通过进行一项荟萃分析，探讨血管内皮生长因子（VEGF）+405 G/C多态性是否与乳腺癌（BC）易感性相关。
从PubMed、Embase和谷歌学术数据库中筛选关于VEGF +405 G/C多态性与BC风险关联的出版物。由三位独立评审员从研究中提取数据。使用STATA 12.0软件进行荟萃分析，并计算比值比（OR）及95%置信区间（CI）。
最终检索到10项病例对照研究，共纳入8855例BC患者和9393例对照。在5种模型下，总体人群中VEGF +405 G/C多态性与BC风险之间未发现显著关联（C vs G：OR = 1.001，95% CI = 0.896 - 1.119，p = 0.987；CC vs GG：OR = 1.006，95% CI = 0.853 - 1.186，p = 0.997；CG vs GG：OR = 0.985，95% CI = 0.823 - 1.178，p = 0.779；CC vs CGs/GG：OR = 1.019，95% CI = 0.921 - 1.127，p = 0.722；CC/CG vs GG：OR = 0.985，95% CI = 0.835 - 1.162，p = 0.862），按种族进行的亚组分析结果亦是如此。
我们的研究证实VEGF +405 G/C多态性与BC风险之间不存在关联。
