Luo Haiqing, Shao Yiming, Yao Na, Chen Xiaoyi, Hu Liren, He Taiping
Oncology Center, the Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
J BUON. 2015 Jul-Aug;20(4):1142-53.
Observational studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and cancer risk. However, conflicting results have been obtained. To derive a precise estimate of the association, a systematic review and meta-analysis were conducted.
This study followed the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, Medline, Embase and Web of Knowledge were systematically searched for relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the allelic and genotypic comparisons according to the homozygous, heterozygous, dominant, and recessive genetic models. Between-study heterogeneity was quantified through I2 statistics, and publication bias was appraised by using funnel plots. Sensitivity analyses were conducted to evaluate the robustness of the meta-analysis findings.
Meta-analysis of 9 studies involving 2491 cases and 3380 controls did not reveal any significant association of the HMOX-1 (GT)n and 413A>T polymorphisms with cancer risk. Stratified analysis by ethnicity showed a statistically significant association between (GT)n repeat length variant and susceptibility to cancer for the heterozygous genetic model among Asian populations (OR=1.42, 95% CI: 1.04-1.95, Pheterogeneity=0.218), which is a robust finding according to sensitivity analysis. Funnel plot inspection did not reveal any publication bias.
In conclusion, this study comprehensively examined the available literature on the association of HMOX-1 (GT)n and 413A>T polymorphisms with cancer risk. Meta-analysis results suggest (GT)n repeat length polymorphism as a potential susceptibility variant for cancer in Asians. Additional large-scale and well-designed studies are needed to confirm these results.
观察性研究近来聚焦于血红素加氧酶-1（HMOX1）基因启动子多态性与癌症风险之间的关联。然而，研究结果相互矛盾。为了得出该关联的精确估计值，我们进行了一项系统评价和荟萃分析。
本研究遵循系统评价和荟萃分析的首选报告项目指南。系统检索了PubMed、Medline、Embase和Web of Knowledge上的相关研究。根据纯合子、杂合子、显性和隐性遗传模型，计算等位基因和基因型比较的汇总比值比（OR）和95%置信区间（CI）。通过I2统计量对研究间异质性进行量化，并使用漏斗图评估发表偏倚。进行敏感性分析以评估荟萃分析结果的稳健性。
对9项研究（涉及2491例病例和3380例对照）的荟萃分析未发现HMOX-1（GT）n和413A>T多态性与癌症风险之间存在任何显著关联。按种族进行的分层分析显示，在亚洲人群中，杂合子遗传模型下（GT）n重复长度变异与癌症易感性之间存在统计学显著关联（OR=1.42，95%CI：1.04-1.95，P异质性=0.218），根据敏感性分析，这是一个可靠的发现。漏斗图检查未发现任何发表偏倚。
总之，本研究全面审查了关于HMOX-1（GT）n和413A>T多态性与癌症风险关联的现有文献。荟萃分析结果表明，（GT）n重复长度多态性是亚洲人患癌的潜在易感变异。需要更多大规模且设计良好的研究来证实这些结果。
