Shum H P, Chan K C, Wong H Y, Yan W W
Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Department of Anaesthesia and Intensive Care, Tuen Mun Hospital, Tuen Mun, Hong Kong.
Hong Kong Med J. 2015 Dec;21(6):490-8. doi: 10.12809/hkmj144445. Epub 2015 Sep 29.
To evaluate the clinical outcome (180-day mortality) of very elderly critically ill patients (age ≥80 years) and compare with those aged 60 to 79 years.
Historical cohort study.
Regional hospital, Hong Kong.
Patients aged ≥60 years admitted between 1 January 2009 and 31 December 2013 to the Intensive Care Unit of the hospital.
Over 5 years, 4226 patients aged ≥60 years were admitted (55.5% total intensive care unit admissions), of whom 32.8% were aged ≥80 years. The proportion of patients aged ≥80 years increased over 5 years. As expected, those aged ≥80 years carried more significant co-morbidities and a higher disease severity compared with those aged 60 to 79 years. They required more mechanical ventilatory support, were less likely to receive renal replacement therapy, and had a higher intensive care unit/hospital/180-day mortality compared with those aged 60 to 79 years. Nonetheless, 71.8% were discharged home and 62.2% survived >180 days following intensive care unit admission. Cox regression analysis revealed that Acute Physiology and Chronic Health Evaluation IV-minus-Age score, emergency admission, intensive care unit admission due to cardiovascular problem, neurosurgical cases, presence of significant co-morbidities (diabetes mellitus, metastatic carcinoma, leukaemia, or myeloma), and requirement for mechanical ventilation independently predicted 180-day mortality.
The proportion of critically ill patients aged ≥80 years increased over a 5-year period. Despite having more significant co-morbidities, greater disease severity, and higher intensive care unit/hospital/180-day mortality rate compared with those aged 60 to 79 years, 71.8% of those ≥80 years could be discharged home and 62.2% survived >180 days following intensive care unit admission. Disease severity, presence of co-morbidities, requirement for mechanical ventilation, emergency cases, and admission diagnosis independently predicted 180-day mortality.
评估高龄危重症患者(年龄≥80岁)的临床结局(180天死亡率),并与60至79岁的患者进行比较。
历史性队列研究。
香港地区医院。
2009年1月1日至2013年12月31日期间入住该医院重症监护病房的年龄≥60岁的患者。
在5年期间,共有4226名年龄≥60岁的患者入院(占重症监护病房总入院人数的55.5%),其中32.8%的患者年龄≥80岁。80岁及以上患者的比例在5年中有所增加。正如预期的那样,与60至79岁的患者相比,80岁及以上的患者合并症更多,疾病严重程度更高。他们需要更多的机械通气支持,接受肾脏替代治疗的可能性更小,与60至79岁的患者相比,其重症监护病房/医院/180天死亡率更高。尽管如此,71.8%的患者出院回家,62.2%的患者在重症监护病房入院后存活超过180天。Cox回归分析显示,急性生理与慢性健康状况评估IV减去年龄评分、急诊入院、因心血管问题入住重症监护病房、神经外科病例、存在重大合并症(糖尿病、转移性癌、白血病或骨髓瘤)以及需要机械通气可独立预测180天死亡率。
在5年期间,80岁及以上危重症患者的比例有所增加。尽管与60至79岁的患者相比,80岁及以上的患者合并症更多、疾病严重程度更高、重症监护病房/医院/180天死亡率更高,但71.8%的80岁及以上患者可以出院回家,62.2%的患者在重症监护病房入院后存活超过180天。疾病严重程度、合并症的存在、机械通气的需求、急诊病例以及入院诊断可独立预测180天死亡率。