Troy Lauren K, Young Iven H, Lau Edmund M T, Corte Tamera J
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Sydney Medical School, University of Sydney, Sydney, Australia.
Respirology. 2016 Aug;21(6):1005-14. doi: 10.1111/resp.12650. Epub 2015 Sep 29.
Exercise limitation is a common feature in idiopathic interstitial pneumonia (IIP). There are multiple contributing pathophysiological mechanisms, including ventilatory mechanical limitation, impaired gas exchange, pulmonary vascular insufficiency and peripheral muscle dysfunction. Progressive exertional dyspnoea and functional incapacity impact significantly on quality of life. Exercise-induced desaturation is frequently observed and is predictive of poorer outcomes. Tests to assess the cardiorespiratory system under stress (e.g. cardiopulmonary exercise testing and the 6-min walk test) can provide important physiologic and prognostic information as adjuncts to resting measurements of lung function. Despite many advances in understanding disease mechanisms, therapies to improve exercise capacity, symptom burden and quality of life are lacking. Exercise training and supplemental oxygen are two potential interventions that require closer evaluation in patients with IIP.
运动受限是特发性间质性肺炎（IIP）的一个常见特征。存在多种起作用的病理生理机制，包括通气机械性受限、气体交换受损、肺血管功能不全和外周肌肉功能障碍。进行性运动性呼吸困难和功能丧失对生活质量有显著影响。运动诱发的血氧饱和度下降经常被观察到，并且预示着更差的预后。评估应激状态下心肺系统的测试（如心肺运动试验和6分钟步行试验）作为肺功能静息测量的辅助手段，可以提供重要的生理和预后信息。尽管在理解疾病机制方面取得了许多进展，但仍缺乏改善运动能力、症状负担和生活质量的疗法。运动训练和补充氧气是两种需要在IIP患者中进行更深入评估的潜在干预措施。
