Zeidler C, Ständer S
Department of Dermatology, Center for Chronic Pruritus, University Hospital of Münster, Germany.
Eur J Pain. 2016 Jan;20(1):37-40. doi: 10.1002/ejp.767. Epub 2015 Sep 28.
Prurigo nodularis (PN) is characterized by multiple hyperkeratotic nodules, papules and the presence of intensive pruritus. This leads to an impaired quality of life and high burden due not only to the severe itch but also the chronic, skin lesions and lack of treatment options. The pathogenesis of PN is not completely clarified. Previous studies have demonstrated just how important the interaction between cutaneous nerve fibres and immune cells is. Besides a reduced intraepidermal nerve fibre density, there are increased dermal levels of neuropeptides such as substance P, calcitonin gene-related peptide and nerve growth factor, as well as a predominant presence of eosinophils and mast cells. An interaction of these factors results in a complex relationship which will be discussed in this article.
结节性痒疹（PN）的特征是有多个角化过度的结节、丘疹，并伴有剧烈瘙痒。这不仅会导致生活质量受损，还会带来沉重负担，这不仅是因为严重瘙痒，还因为慢性皮肤病变以及缺乏治疗选择。PN的发病机制尚未完全阐明。先前的研究已经证明了皮肤神经纤维与免疫细胞之间的相互作用有多重要。除了表皮内神经纤维密度降低外，皮肤中神经肽如P物质、降钙素基因相关肽和神经生长因子的水平也有所升高，同时嗜酸性粒细胞和肥大细胞大量存在。这些因素之间的相互作用导致了一种复杂的关系，本文将对此进行讨论。
