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本文引用的文献

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Identifying responders and nonresponders to interferon therapy in multiple sclerosis.识别多发性硬化症中干扰素治疗的应答者和无应答者。
Degener Neurol Neuromuscul Dis. 2014 Apr 1;4:75-85. doi: 10.2147/DNND.S42734. eCollection 2014.
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A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity.一项遗传药理学研究表明 SLC9a9 与多发性硬化症的疾病活动有关。
Ann Neurol. 2015 Jul;78(1):115-27. doi: 10.1002/ana.24429. Epub 2015 May 14.
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Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis.基于钆的磁共振成像对多发性硬化软脑膜炎症的特征分析
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PML in a patient with lymphocytopenia treated with dimethyl fumarate.一名淋巴细胞减少症患者在接受富马酸二甲酯治疗后发生进行性多灶性白质脑病。
N Engl J Med. 2015 Apr 9;372(15):1476-8. doi: 10.1056/NEJMc1415408.
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Alemtuzumab for the treatment of multiple sclerosis.阿仑单抗用于治疗多发性硬化症。
Ther Clin Risk Manag. 2015 Mar 31;11:525-34. doi: 10.2147/TCRM.S80112. eCollection 2015.
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No quiet surrender: molecular guardians in multiple sclerosis brain.绝不轻易屈服:多发性硬化症大脑中的分子守护者
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7
Patients report worse MS symptoms after menopause: findings from an online cohort.患者报告绝经后多发性硬化症状加重:一项在线队列研究的结果
Mult Scler Relat Disord. 2015 Jan;4(1):18-24. doi: 10.1016/j.msard.2014.11.009. Epub 2014 Dec 9.
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Pathological mechanisms in progressive multiple sclerosis.进行性多发性硬化症的病理机制。
Lancet Neurol. 2015 Feb;14(2):183-93. doi: 10.1016/S1474-4422(14)70256-X.
9
Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic.药物整合应激反应增强可保护少突胶质细胞,并为多发性硬化症提供一种潜在的治疗方法。
Nat Commun. 2015 Mar 13;6:6532. doi: 10.1038/ncomms7532.
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Multiple sclerosis-a quiet revolution.多发性硬化症——一场悄然的变革。
Nat Rev Neurol. 2015 Mar;11(3):134-42. doi: 10.1038/nrneurol.2015.14. Epub 2015 Feb 17.

研究人员扩大对多发性硬化症进展形式的关注:确定疾病起始的努力可能会为治疗提供线索。

Researchers Expand Focus on Progressive Forms Of Multiple Sclerosis: Efforts to Pinpoint the Beginning of Disease May Yield Clues to Treatment.

作者信息

Worley Susan

出版信息

P T. 2015 Sep;40(9):584-605.

PMID:26417178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4571847/
Abstract

With disease-modifying treatments available for relapsing-remitting multiple sclerosis (MS), the quest for therapies for progressive MS has become a key focus of research.

摘要

随着针对复发缓解型多发性硬化症(MS)的疾病修正治疗方法的出现,寻找进行性MS的治疗方法已成为研究的关键重点。