Nesfatin-1：作为新型抗肥胖治疗方法的作用
Nesfatin-1: role as possible new anti-obesity treatment.
作者信息
Finelli Carmine, Martelli Giuseppe, Rossano Rocco, Padula Maria Carmela, La Sala Nicolina, Sommella Luigi, Tarantino Giovanni
机构信息
Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, Chiaromonte, Potenza, Italy.
Department of Science, University of Basilicata, Potenza, Viale dell'Ateneo Lucano, 10, 85100, Italy.
出版信息
EXCLI J. 2014 May 26;13:586-91. eCollection 2014.
Abstract
In this article, we review on the current concepts about Nesfatin-1 as a new anti-obesity treatment and evaluate the existing issues in the context of this knowledge and the available literature. The intent is to enable clinicians to know Nesfatin-1 as a new anti-obesity treatment and make rational decisions based on this perspective as possible clinical application. Future research should seek to clarify whether Nesfatin-1 would be beneficial in the management of obesity.
摘要
在本文中，我们回顾了关于Nesfatin-1作为一种新型抗肥胖治疗方法的当前概念，并结合这一知识背景和现有文献评估了现存问题。目的是使临床医生了解Nesfatin-1作为一种新型抗肥胖治疗方法，并基于这一观点在可能的临床应用中做出合理决策。未来的研究应致力于阐明Nesfatin-1在肥胖管理中是否有益。
相似文献
1
Nesfatin-1: role as possible new anti-obesity treatment.Nesfatin-1：作为新型抗肥胖治疗方法的作用
EXCLI J. 2014 May 26;13:586-91. eCollection 2014.
2
Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment.肥胖人群脑脊液/新型饱腹分子 nesfatin-1/NUCB-2 比值降低：nesfatin-1/NUCB-2 抵抗的证据及其对肥胖治疗的影响。
J Clin Endocrinol Metab. 2011 Apr;96(4):E669-73. doi: 10.1210/jc.2010-1782. Epub 2011 Jan 20.
3
The evaluation of Nesfatin-1 levels in patients with OSAS associated with metabolic syndrome.阻塞性睡眠呼吸暂停低通气综合征合并代谢综合征患者中Nesfatin-1水平的评估。
J Endocrinol Invest. 2015 Apr;38(4):463-9. doi: 10.1007/s40618-014-0216-0. Epub 2014 Nov 29.
4
; ASSOCIATION OF CIRCULATING ADIPONECTIN, RESISTIN, IRISIN, NESFATIN-1, APELIN-12 AND OBESTATIN LEVELS WITH HYPERTENSION AND OBESITY.循环脂联素、抵抗素、鸢尾素、nesfatin-1、Apelin-12和肥胖抑制素水平与高血压和肥胖的关联
Georgian Med News. 2020 Jul-Aug(304-305):43-48.
5
Nesfatin-1: its role in the diagnosis and treatment of obesity and some psychiatric disorders.内脂素-1：其在肥胖症及某些精神障碍的诊断与治疗中的作用
Methods Mol Biol. 2013;963:327-38. doi: 10.1007/978-1-62703-230-8_20.
6
Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism.通过饮食和运动增加肥胖雄性小鼠下丘脑核结合蛋白 2 水平并减少下丘脑炎症，可缓解肥胖相关的性腺功能减退症。
Neuropeptides. 2019 Apr;74:34-43. doi: 10.1016/j.npep.2018.10.005. Epub 2018 Nov 1.
7
Is There a Relationship between Obstructive Sleep Apnea Syndrome Severity and Nesfatin-1?阻塞性睡眠呼吸暂停综合征严重程度与Nesfatin-1之间存在关联吗？
Respiration. 2015;90(2):105-10. doi: 10.1159/000431180. Epub 2015 Jun 16.
8
Metabolic and Cardiovascular Actions of Nesfatin-1: Implications in Health and Disease.内脂素-1的代谢和心血管作用：对健康与疾病的影响
Curr Pharm Des. 2017;23(10):1453-1464. doi: 10.2174/1381612823666170130154407.
9
Nesfatin-1: an overview and future clinical application.内脂素-1：概述与未来临床应用
Endocr J. 2009;56(4):537-43. doi: 10.1507/endocrj.k09e-117. Epub 2009 May 20.
10
Study of the effects of nesfatin-1 on gastric function in obese rats.研究 nesfatin-1 对肥胖大鼠胃功能的影响。
World J Gastroenterol. 2017 Apr 28;23(16):2940-2947. doi: 10.3748/wjg.v23.i16.2940.
引用本文的文献
1
Examining the Potential Applicability of Orexigenic and Anorexigenic Peptides in Veterinary Medicine for the Management of Obesity in Companion Animals.研究促食欲肽和抑食欲肽在兽医学中用于伴侣动物肥胖管理的潜在适用性。
Curr Issues Mol Biol. 2024 Jul 1;46(7):6725-6745. doi: 10.3390/cimb46070401.
2
High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying.高脂饮食增强胃收缩性，但消除了Nesfatin-1诱导的胃排空抑制作用。
J Neurogastroenterol Motil. 2021 Apr 30;27(2):265-278. doi: 10.5056/jnm20206.
3
Does nesfatin-1 influence the hypothalamic-pituitary-gonadal axis in adult males with obstructive sleep apnoea?内脂素-1 是否影响阻塞性睡眠呼吸暂停成年男性的下丘脑-垂体-性腺轴？
Sci Rep. 2019 Aug 5;9(1):11289. doi: 10.1038/s41598-019-47061-3.
4
Saliva and Blood Asprosin Hormone Concentration Associated with Obesity.唾液和血液中阿普洛辛激素浓度与肥胖的关系。
Int J Endocrinol. 2019 Mar 27;2019:2521096. doi: 10.1155/2019/2521096. eCollection 2019.
5
Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome. Relationships to insulin resistance and obesity.成人代谢综合征患者血清中核连蛋白-1和甘丙肽的浓度。与胰岛素抵抗和肥胖的关系。
Saudi Med J. 2019 Jan;40(1):19-25. doi: 10.15537/smj.2019.1.22825.
本文引用的文献
1
Could the improvement of obesity-related co-morbidities depend on modified gut hormones secretion?肥胖相关合并症的改善是否取决于肠道激素分泌的改变？
World J Gastroenterol. 2014 Nov 28;20(44):16649-64. doi: 10.3748/wjg.v20.i44.16649.
2
Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice.内脂素-1 通过激活 STZ 诱导的 2 型糖尿病小鼠的 AMP 激活的蛋白激酶来刺激脂肪酸氧化。
PLoS One. 2013 Dec 31;8(12):e83397. doi: 10.1371/journal.pone.0083397. eCollection 2013.
3
The role of diminishing appetite and serum nesfatin-1 level in patients with burn wound infection.食欲减退和血清核连蛋白-1水平在烧伤创面感染患者中的作用。
Iran Red Crescent Med J. 2013 May;15(5):389-92. doi: 10.5812/ircmj.4198. Epub 2013 May 5.
4
Peripheral effects of nesfatin-1 on glucose homeostasis.内脂素-1 对葡萄糖稳态的外周作用。
PLoS One. 2013 Aug 15;8(8):e71513. doi: 10.1371/journal.pone.0071513. eCollection 2013.
5
Liver and plasma nesfatin-1 responses to 6 weeks of treadmill running with or without zizyphus jujuba liquid extract in female rat.雌性大鼠在有或无酸枣液体提取物的情况下进行6周跑步机跑步后肝脏和血浆中核连蛋白-1的反应。
Int J Endocrinol Metab. 2013 Spring;11(2):95-101. doi: 10.5812/ijem.8438. Epub 2013 Apr 1.
6
Role of nesfatin-1 in a rat model of visceral hypersensitivity.内脂素-1 在内脏高敏感大鼠模型中的作用。
World J Gastroenterol. 2013 Jun 14;19(22):3487-93. doi: 10.3748/wjg.v19.i22.3487.
7
Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats.内脂素-1/NUCB2 作为调节大鼠睡眠的潜在新元素。
PLoS One. 2013;8(4):e59809. doi: 10.1371/journal.pone.0059809. Epub 2013 Apr 1.
8
Central and peripheral expression and distribution of NUCB2/nesfatin-1.NUCB2/nesfatin-1在中枢和外周的表达及分布
Curr Pharm Des. 2013;19(39):6935-40. doi: 10.2174/138161281939131127124814.
9
Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus.中间尿皮质素 3 和 2 型促肾上腺皮质素释放因子受体在能量平衡调节中的作用：腹内侧下丘脑的关键作用。
Front Endocrinol (Lausanne). 2013 Jan 7;3:180. doi: 10.3389/fendo.2012.00180. eCollection 2012.
10
Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis.分泌饱腹感分子 Nesfatin-1 的结节下丘脑神经元在反常（快速眼动）睡眠动态平衡中起着关键作用。
PLoS One. 2012;7(12):e52525. doi: 10.1371/journal.pone.0052525. Epub 2012 Dec 27.
Zotero 插件