Anjaneyulu G, Nagaiah G
Department of Social and Preventive Medicine, Osmania Medical College, Hyderabad, Andhra Pradesh.
Indian J Public Health. 1989 Jan-Mar;33(1):5-8.
Between June 1986 and September 1987 a population of 100 families was dewormed every 3 months (quarter) by using a single dose of pyrantel. Stool samples were examined by Kato's thick smear method; height (m), weight (kg), hemoglobin concentration (g/dl) and clinical morbidity were recorded before each deworming treatment. Clinical morbidity was recorded in another 100 control families who did not receive anthelmlntics. There were 477 and 490 individuals in the study and the control families respectively. In the study group the prevalence of roundworm was reduced from 10.3% to to 0% and that of hookworm infection was reduced from 2.9% to 0% after 2 quarters. At the end of the 4th quarter the mean hemoglobin rose by 0.1 g/dl (P less than 0.01) and the mean BMI increased by 0.37 (P less than 0.01). There was a significant reduction in the clinical morbidity in the study group compared with the control group (P less than 0.05). There were no side effects reported to pyrantel treatment. Thus quarterly treatment with pyrantel was found to be effective in keeping roundworm and hookworm prevalence at 0% in an industrial township.
1986年6月至1987年9月期间，100户家庭每3个月（一个季度）使用单剂量的噻嘧啶进行驱虫。粪便样本采用加藤厚涂片法检查；在每次驱虫治疗前记录身高（米）、体重（千克）、血红蛋白浓度（克/分升）和临床发病率。在另外100户未接受驱虫药治疗的对照家庭中记录临床发病率。研究组和对照组分别有477人和490人。在研究组中，经过两个季度后，蛔虫感染率从10.3%降至0%，钩虫感染率从2.9%降至0%。在第4季度末，平均血红蛋白升高了0.1克/分升（P<0.01），平均体重指数增加了0.37（P<0.01）。与对照组相比，研究组的临床发病率显著降低（P<0.05）。未报告噻嘧啶治疗的副作用。因此，在一个工业城镇，每季度使用噻嘧啶进行治疗可有效将蛔虫和钩虫感染率维持在0%。
