蛋白质组学方法在腹主动脉瘤患者中鉴定循环生物标志物
Proteomic approaches to identify circulating biomarkers in patients with abdominal aortic aneurysm.
作者信息
Bylund Dan, Henriksson Anders E
机构信息
Department of Natural Sciences, Mid Sweden University Sundsvall, Sweden.
Department of Natural Sciences, Mid Sweden University Sundsvall, Sweden ; Department of Laboratory Medicine, Sundsvall County Hospital Sweden.
出版信息
Am J Cardiovasc Dis. 2015 Sep 15;5(3):140-5. eCollection 2015.
Abstract
Abdominal aortic aneurysm (AAA) is a common condition with high mortality when ruptured. Most clinicians agree that small AAAs are best managed by ultrasonographic surveillance. However, it has been stated in recent reviews that a serum/plasma biomarker that predicts AAA rupture risk would be a powerful tool in stratifying patients with small AAAs. Identification of such circulating biomarkers with traditional hypothesis driven studies has been unsuccessful. In this review we summarize six studies using different proteomic approaches to find new, potential plasma AAA biomarker candidates. In conclusion, by using proteomic approaches novel potential plasma biomarkers for AAA have been identified.
摘要
腹主动脉瘤（AAA）是一种常见疾病，破裂时死亡率很高。大多数临床医生认为，小型腹主动脉瘤最好通过超声监测进行管理。然而，最近的综述指出，一种能够预测腹主动脉瘤破裂风险的血清/血浆生物标志物将是对小型腹主动脉瘤患者进行分层的有力工具。通过传统的假设驱动研究来识别此类循环生物标志物尚未成功。在本综述中，我们总结了六项使用不同蛋白质组学方法来寻找新的、潜在的血浆腹主动脉瘤生物标志物候选物的研究。总之，通过使用蛋白质组学方法，已鉴定出用于腹主动脉瘤的新型潜在血浆生物标志物。
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