Kathuriya Pargatsingh T, Bartake Anirudha R, Palaskar Sangeeta J, Narang Bindiya R, Patil Swati S, Pawar Rasika B
Post Graduate Student, Department of Oral & Maxillofacial Pathology, Sinhgad Dental College & Hospital , Pune, India .
Assistant Professor, Department of Oral & Maxillofacial Pathology, Sinhgad Dental College & Hospital , Pune, India .
J Clin Diagn Res. 2015 Jul;9(7):ZC61-4. doi: 10.7860/JCDR/2015/12656.6223. Epub 2015 Jul 1.
Oral Squamous Cell Carcinoma (OSCC) remains a serious health problem worldwide. Prognosis of OSCC is poor and long term survival rate still remains below 50%. Angiogenesis or neovascularisation plays an important role in tumour progression and metastasis. Mast cells have been implicated in promoting tumour angiogenesis, especially of digestive tract, little is known in OSCC.
AIM & OBJECTIVE: To study the correlation between blood vessel density (BVD) and mast cell density (MCD) in different grades of OSCC.
Thirty eight paraffin blocks of different grades of OSCC were retrieved from the department and sections were stained with CD34 followed by counterstaining with toluidine blue. The slides were then analysed using Leica Software (Version 4.5).
Mean BVD and MCD were found to be increased in OSCC as compared to normal mucosa. Increase in BVD with co-current increase in MCD was also observed in different grades of OSCC.
From our study, it was concluded that, mast cells play a major role in promoting tumour angiogenesis. But, as the grade of the tumour increases, other angiogenic factors may play a more significant role than mast cells in tumour progression.
口腔鳞状细胞癌（OSCC）在全球范围内仍然是一个严重的健康问题。OSCC的预后较差，长期生存率仍低于50%。血管生成或新血管形成在肿瘤进展和转移中起重要作用。肥大细胞被认为在促进肿瘤血管生成中起作用，尤其是在消化道肿瘤中，但在OSCC中的情况知之甚少。
研究不同分级的OSCC中血管密度（BVD）与肥大细胞密度（MCD）之间的相关性。
从科室获取38个不同分级的OSCC石蜡块，切片先用CD34染色，然后用甲苯胺蓝复染。然后使用徕卡软件（版本4.5）对切片进行分析。
与正常黏膜相比，OSCC中的平均BVD和MCD均升高。在不同分级的OSCC中还观察到BVD随着MCD的同步增加而增加。
从我们的研究得出结论，肥大细胞在促进肿瘤血管生成中起主要作用。但是，随着肿瘤分级的增加，在肿瘤进展中其他血管生成因子可能比肥大细胞发挥更重要的作用。
