Bratek Agnieszka, Koźmin-Burzyńska Agnieszka, Górniak Eliza, Krysta Krzysztof
Department of Psychiatry and Psychotherapy, Independent Public Clinical Hospital No. 7 of Silesian Medical University, Ziołowa 45-47, Katowice, Poland,
Psychiatr Danub. 2015 Sep;27 Suppl 1:S339-43.
Cushing's syndrome is the term used to describe a set of symptoms associated with hypercortisolism, which in most cases is caused by hypophysial microadenoma over-secreting adrenocorticotropic hormone. This endocrine disorder is often associated with psychiatric comorbidities. The most important include mood disorders, psychotic disorders, cognitive dysfunctions and anxiety disorders.
The aim of this article was to review the prevalence, symptoms and consequences of psychiatric disorders in the course of Cushing's syndrome. We therefore performed a literature search using the following keywords: Cushing's syndrome and psychosis, Cushing's syndrome and mental disorders, Cushing's syndrome and depression, Cushing's syndrome and anxiety.
The most prevalent psychiatric comorbidity of Cushing's syndrome is depression. Psychiatric manifestations can precede the onset of full-blown Cushing's syndrome and therefore be misdiagnosed. Despite the fact that treatment of the underlying endocrine disease in most cases alleviates psychiatric symptoms, the loss of brain volume persists.
It is important to be alert to the symptoms of hypercortisolism in psychiatric patients to avoid misdiagnosis and enable them receiving adequate treatment.
库欣综合征是用于描述一组与皮质醇增多症相关症状的术语，在大多数情况下，其由分泌促肾上腺皮质激素的垂体微腺瘤引起。这种内分泌紊乱常伴有精神疾病共病。其中最重要的包括情绪障碍、精神障碍、认知功能障碍和焦虑症。
本文旨在综述库欣综合征病程中精神障碍的患病率、症状及后果。因此，我们使用以下关键词进行了文献检索：库欣综合征与精神病、库欣综合征与精神障碍、库欣综合征与抑郁症、库欣综合征与焦虑症。
库欣综合征最常见的精神共病是抑郁症。精神症状可先于典型库欣综合征发作，因此可能被误诊。尽管大多数情况下治疗潜在的内分泌疾病可缓解精神症状，但脑容量的减少仍会持续。
对精神科患者的皮质醇增多症症状保持警惕很重要，以避免误诊并使他们能接受适当治疗。
