Li Yu-Cheng, Liu Ya-Min, Shen Ji-Duo, Chen Jun-Jie, Pei Yang-Yi, Fang Xiao-Yan
College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Molecules. 2016 Oct 13;21(10):1341. doi: 10.3390/molecules21101341.
Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy.
已知长期暴露于糖皮质激素会导致抑郁和代谢紊乱。改善长期接受糖皮质激素治疗患者的异常代谢状态以及抑郁样行为至关重要。本研究旨在探讨白藜芦醇对慢性注射皮质酮所致抑郁样行为和代谢异常的影响。雄性ICR小鼠皮下注射皮质酮（40 mg/kg），持续三周。在给予皮质酮前30分钟，通过灌胃给予白藜芦醇（50和100 mg/kg）、氟西汀（20 mg/kg）和吡格列酮（10 mg/kg）。行为测试表明，白藜芦醇显著逆转了皮质酮诱导的抑郁样行为，包括在强迫游泳试验中蔗糖偏好降低和不动时间增加。此外，白藜芦醇还增加了皮质酮处理小鼠的胰岛素分泌，降低了血清葡萄糖水平并改善了血脂谱，而对正常小鼠无影响。然而，氟西汀仅逆转抑郁样行为，吡格列酮仅预防皮质酮诱导的血脂异常。此外，白藜芦醇和吡格列酮降低了血清胰高血糖素和皮质酮水平。目前的结果表明，白藜芦醇可以改善皮质酮诱导的抑郁样行为和代谢异常，这表明白藜芦醇的多种作用可能对与长期糖皮质激素治疗相关的抑郁症和/或代谢综合征患者有益。
