Russell David W, Grompe Markus
Departments of Medicine and Biochemistry, University of Washington, Seattle, Washington, USA.
Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA.
Nat Genet. 2015 Oct;47(10):1104-5. doi: 10.1038/ng.3407.
Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.
腺相关病毒（AAV）载体已被广泛应用于基因治疗。一项新的研究引发了对这种方法的担忧，该研究报告称，2型腺相关病毒血清型的染色体插入似乎会激活人类肝细胞癌中的原癌基因。
