Llor J, Vázquez J J
Departamento de Histología y Patología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Rev Esp Fisiol. 1989;45 Suppl:49-54.
The changes of the serum biochemical features induced by cyanamide, a drug used in the pharmacological treatment of alcoholism, were studied in Wistar rats. Sixty five Wistar rats were divided into 6 groups, 4 experimental and 2 control. Two experimental groups received cyanamide intraperitoneally, at a dose of 1 and 16 mg per kg of body weight, for 8 weeks. One experimental group received CCl4 and the other one CCl4 and cyanamide for 13 weeks. In addition to a delay in the increase of body weight as compared with the control group, the rats receiving cyanamide underwent a marked dispersion of the transaminase and LDH values. This could be explained by the double effect of cyanamide: its capacity to depress the cellular activity (lowered synthesis of proteins, transaminase and LDH among them) and cellular damage. Therefore, some animals showed a marked depression of protein synthesis, causing low enzyme values while cytolysis prevailed in the rest as seen in higher enzyme values. When cyanamide and CCl4 were employed simultaneously, the cyanamide tended to diminish the higher enzyme values caused by CCl4 when used alone. These findings can explain why patients on cyanamide may develop severe liver damage without serious alterations in tests for liver function.
对用于酒精中毒药物治疗的药物氨基氰诱导的血清生化特征变化，在Wistar大鼠中进行了研究。65只Wistar大鼠被分为6组，4个实验组和2个对照组。两个实验组腹腔注射氨基氰，剂量为每千克体重1毫克和16毫克，持续8周。一个实验组接受四氯化碳，另一个实验组接受四氯化碳和氨基氰，持续13周。与对照组相比，接受氨基氰的大鼠除体重增加延迟外，转氨酶和乳酸脱氢酶值出现明显离散。这可以用氨基氰的双重作用来解释：其抑制细胞活性的能力（其中蛋白质、转氨酶和乳酸脱氢酶的合成降低）以及细胞损伤。因此，一些动物蛋白质合成明显受抑，导致酶值较低，而其余动物则以细胞溶解为主，表现为酶值较高。当同时使用氨基氰和四氯化碳时，氨基氰倾向于降低单独使用四氯化碳时引起的较高酶值。这些发现可以解释为什么服用氨基氰的患者可能会出现严重肝损伤，而肝功能检查却没有严重改变。
