Idoate M A, Vázquez J J
Department of Pathology, University of Navarre, Pamplona, Spain.
Int J Exp Pathol. 1992 Dec;73(6):699-708.
Cyanamide, a drug used in alcohol aversion therapy, induces a distinctive liver cell lesion, both in human beings and rats. The lesion consists of cytoplasmic inclusion bodies which give a ground-glass appearance to the hepatocytes. In human beings the inclusion bodies do not persist but disappear some time after withdrawal of the drug. In order to confirm their disappearance and determine how they regress rats were treated with cyanamide (32 mg/kg) for 6 months before partial lobectomy. At this time, inclusion bodies were observed. After a period without further treatment (5-19 weeks) the animals were killed and a marked decrease in the number of inclusion bodies was observed, paralleling the period of time without treatment. Inclusion bodies regress as a result of glycogen removal by enzymatic activity of the smooth endoplasmic reticulum which then undergoes hyperplasia, plus a process of autophagocytosis and necrosis of inclusion-body-bearing hepatocytes which are then phagocytosed by macrophages.
氨基氰是一种用于酒精厌恶疗法的药物，在人类和大鼠中都会引发一种独特的肝细胞病变。这种病变由细胞质包涵体组成，使肝细胞呈现出毛玻璃样外观。在人类中，包涵体不会持续存在，而是在停药后的一段时间内消失。为了证实它们的消失并确定其消退方式，在部分肝叶切除术前，用氨基氰（32毫克/千克）对大鼠进行了6个月的治疗。此时，观察到了包涵体。在未经进一步治疗的一段时间（5 - 19周）后，处死动物，观察到包涵体数量显著减少，这与未治疗的时间段平行。包涵体的消退是由于滑面内质网的酶活性去除糖原，随后滑面内质网增生，加上含包涵体的肝细胞发生自噬和坏死过程，然后被巨噬细胞吞噬。
