基于自组装白蛋白的纳米探针用于体内比率型光声 pH 成像。
A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging.
机构信息
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Department of Polymer Science and Engineering, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, China.
出版信息
Adv Mater. 2015 Nov 18;27(43):6820-7. doi: 10.1002/adma.201503194. Epub 2015 Sep 29.
A photoacoustic nanoprobe is self-assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy-to-operate, and have depth-independent accuracy for real-time in vivo pH imaging of entire tumors. These features make them promising for future cancer prognosis and therapeutic planning.
一种光声纳米探针由人血清白蛋白和两种染料分子自组装而成，其中一种染料分子对 pH 值不敏感，另一种染料分子对 pH 值敏感。该探针和定量比率光声 pH 成像方法具有高安全性、易于操作以及对整个肿瘤进行实时体内 pH 成像的深度独立性和准确性等特点，有望用于癌症预后和治疗计划。
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