Zhang Peisen, Li Wenyue, Liu Chuang, Qin Feng, Lu Yijie, Qin Meng, Hou Yi
College of Life Science and Technology Beijing University of Chemical Technology Beijing China.
Department of Chemistry University of Toronto Toronto Ontario Canada.
Exploration (Beijing). 2023 Oct 28;3(6):20230070. doi: 10.1002/EXP.20230070. eCollection 2023 Dec.
Although the extraordinary progress has been made in molecular biology, the prevention of cancer remains arduous. Most solid tumours exhibit both spatial and temporal heterogeneity, which is difficult to be mimicked in vitro. Additionally, the complex biochemical and immune features of tumour microenvironment significantly affect the tumour development. Molecular imaging aims at the exploitation of tumour-associated molecules as specific targets of customized molecular probe, thereby generating image contrast of tumour markers, and offering opportunities to non-invasively evaluate the pathological characteristics of tumours in vivo. Particularly, there are no "standard markers" as control in clinical imaging diagnosis of individuals, so the tumour pathological characteristics-responsive nanoprobe-based quantitative molecular imaging, which is able to visualize and determine the accurate content values of heterogeneous distribution of pathological molecules in solid tumours, can provide criteria for cancer diagnosis. In this context, a variety of "smart" quantitative molecular imaging nanoprobes have been designed, in order to provide feasible approaches to quantitatively visualize the tumour-associated pathological molecules in vivo. This review summarizes the recent achievements in the designs of these nanoprobes, and highlights the state-of-the-art technologies in quantitative imaging of tumour-associated pathological molecules.
尽管分子生物学已经取得了非凡的进展，但癌症的预防仍然艰巨。大多数实体瘤表现出空间和时间上的异质性，这很难在体外模拟。此外，肿瘤微环境复杂的生化和免疫特征显著影响肿瘤的发展。分子成像旨在利用肿瘤相关分子作为定制分子探针的特异性靶点，从而产生肿瘤标志物的图像对比度，并提供在体内非侵入性评估肿瘤病理特征的机会。特别是，在个体的临床成像诊断中没有“标准标志物”作为对照，因此基于肿瘤病理特征响应的纳米探针的定量分子成像能够可视化并确定实体瘤中病理分子异质分布的准确含量值，可为癌症诊断提供标准。在此背景下，已经设计了多种“智能”定量分子成像纳米探针，以便为在体内定量可视化肿瘤相关病理分子提供可行的方法。本综述总结了这些纳米探针设计方面的最新成果，并突出了肿瘤相关病理分子定量成像的最新技术。
