Department of Cardiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.
Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
Sci Rep. 2017 Feb 17;7:42803. doi: 10.1038/srep42803.
The association of female reproductive factors (FRFs) with cardiovascular risk factors among different population was variable and inconsistent. The objective of this study was to examine the association between FRFs and hypertension, type 2 diabetes mellitus (DM), and long heart-rate-corrected QT interval (LQTc) in Chinese post-menopausal women (Post-MW). A total of 8046 Post-MW from the China Chaoshan Biobank Cohort Study were included for analysis. Logistic regression and general linear regression models were used to estimate the association between FRFs and hypertension, DM, and LQTc. Compared with women with 0 or 1 live birth, increasing risk of hypertension (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.16-1.96), DM (OR, 1.65; 95% CI, 1.22-2.22), and LQTc (OR, 1.45; 95% CI, 1.01-2.09) were observed in women who had five or more live births. Further analysis demonstrated that the association between parity and hypertension, DM, and LQTc was mediated by lifestyle and dyslipidemia. Women with more live births had increased body mass index and waist circumstance, and were inclined to consume more salty food, animal fat, and alcohol, but less meat, vegetable, fish, plant oil, and tea, compared with that had fewer live births (all P < 0.05).
生殖因素（FRFs）与不同人群心血管危险因素的关系是多变且不一致的。本研究旨在探讨中国绝经后妇女（Post-MW）生殖因素与高血压、2 型糖尿病（DM）和长校正 QT 间期（LQTc）的关系。共纳入中国潮汕生物库队列研究的 8046 名 Post-MW 进行分析。采用 logistic 回归和一般线性回归模型来估计 FRFs 与高血压、DM 和 LQTc 之间的关联。与生育 0-1 个活产儿的女性相比，生育 5 个或更多活产儿的女性患高血压（比值比 [OR]，1.51；95%置信区间 [CI]，1.16-1.96）、DM（OR，1.65；95%CI，1.22-2.22）和 LQTc（OR，1.45；95%CI，1.01-2.09）的风险增加。进一步分析表明，生育与高血压、DM 和 LQTc 之间的关联可由生活方式和血脂异常介导。与生育较少的女性相比，生育更多活产儿的女性的体重指数和腰围更高，并且倾向于食用更多的咸食、动物脂肪和酒精，但摄入的肉类、蔬菜、鱼类、植物油和茶较少（均 P<0.05）。
