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PNPLA3基因rs738409多态性与慢性丙型肝炎病毒患者肝脂肪变性及肝纤维化进展的关系：一项荟萃分析

PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.

作者信息

Fan Jia-Hao, Xiang Ming-Que, Li Qing-Ling, Shi Hong-Tao, Guo Jin-Jun

机构信息

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Department of Infectious Diseases, The Ninth People's Hospital of Chongqing, Chongqing, China.

出版信息

Gut Liver. 2016 May 23;10(3):456-63. doi: 10.5009/gnl15261.

DOI:10.5009/gnl15261
PMID:26419236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4849700/
Abstract

BACKGROUND/AIMS: The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients.

METHODS

We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software.

RESULTS

The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG OR, 2.29; 95% CI, 1.57 to 3.35; p<0.05) but not Asian populations. In Caucasians, liver steatosis was also more severe in CHC patients with rs738409 GG (versus CC+CG; OR, 4.33; 95% CI, 2.59 to 7.22; p<0.05). The sensitivity analysis indicated the results of this meta-analysis were stable and no publication bias was detected.

CONCLUSIONS

PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.

摘要

背景/目的：含patatin样磷脂酶结构域蛋白3（PNPLA3）rs738409（C>G）与慢性丙型肝炎（CHC）患者肝脂肪变性或纤维化严重程度之间的相关性尚未达成共识。本荟萃分析旨在准确研究PNPLA3 rs738409（C>G）多态性与CHC患者肝脂肪变性及晚期纤维化之间的关联。

方法

我们对截至2014年12月31日的PubMed、Embase、Web of Science和谷歌学术数据库进行了全面的文献检索。计算了粗比值比（OR）及95%置信区间（CI）。使用Stata 12.0软件进行统计分析。

结果

荟萃分析显示，在白种人中，携带PNPLA3 rs738409 GG的CHC患者肝纤维化严重程度显著更高（与CC+CG相比，OR为2.29；95%CI为1.57至3.35；p<0.05），但在亚洲人群中并非如此。在白种人中，携带rs738409 GG的CHC患者肝脂肪变性也更严重（与CC+CG相比；OR为4.33；95%CI为2.59至7.22；p<0.05）。敏感性分析表明本荟萃分析结果稳定，未检测到发表偏倚。

结论

PNPLA3 rs738409（C>G）与CHC患者晚期肝纤维化和脂肪变性的风险均相关，尤其是在白种人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/4c5d38d1ffde/gnl-10-456f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/f180ca30a2a4/gnl-10-456f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/3abc50696448/gnl-10-456f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/7fc57b08479a/gnl-10-456f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/7530624875cf/gnl-10-456f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/4c5d38d1ffde/gnl-10-456f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/f180ca30a2a4/gnl-10-456f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/3abc50696448/gnl-10-456f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/7fc57b08479a/gnl-10-456f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/7530624875cf/gnl-10-456f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d221/4849700/4c5d38d1ffde/gnl-10-456f5.jpg

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