透皮制剂的体外筛选方法。

In vitro methods for screening transdermal formulations.

作者信息

Tsai Pei-Chin, Lee Serom, Michniak-Kohn Bozena

机构信息

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers - The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

The Center for Dermal Research, New Jersey Center for Biomaterials, Rutgers - The State University of New Jersey, 145 Bevier Rd, Piscataway, NJ 08854, USA.

出版信息

Ther Deliv. 2015;6(9):1043-52. doi: 10.4155/tde.15.58. Epub 2015 Sep 30.

DOI:10.4155/tde.15.58

PMID:26419344

Abstract

This article provides a review of the critical in vitro assays utilized in transdermal drug development. In vitro assays such as percutaneous absorption testing and dissolution (drug release) testing are powerful tools for screening potential transdermal compounds and drug quality control, respectively. Several 2D single-cell cultures and 3D human skin equivalents are available for screening compounds with low irritation and sensitization potential. The role of each assay and its limitations and challenges will be further discussed below.

摘要

本文综述了透皮药物研发中使用的关键体外试验。体外试验，如经皮吸收试验和溶出（药物释放）试验，分别是筛选潜在透皮化合物和进行药物质量控制的有力工具。有几种二维单细胞培养和三维人体皮肤等效物可用于筛选具有低刺激性和致敏性潜力的化合物。每种试验的作用及其局限性和挑战将在下文进一步讨论。