Knešaurek Karin
Department of Radiology, Division of Nuclear Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
World J Nucl Med. 2015 Sep-Dec;14(3):171-7. doi: 10.4103/1450-1147.163246.
The goal was to improve Alzheimer's 2-deoxy-2-(18)F-fluoro-D-glucose ((18)F FDG)-positron emission tomography (PET)/computed tomography (CT) imaging through application of a novel, hybrid Fourier-wavelet windowed Fourier transform (WFT) restoration technique, in order to provide earlier and more accurate clinical results. General Electric Medical Systems downward-looking sonar PET/CT 16 slice system was used to acquire studies. Patient data were acquired according the Alzheimer's disease Neuroimaging Initiative (ADNI) protocol. Here, we implemented Fourier-wavelet regularized restoration, with a Butterworth low-pass filter, order n = 6 and a cut-off frequency f = 0.35 cycles/pixel and wavelet (Daubechies, order 2) noise suppression. The original (PET-O) and restored (PET-R) ADNI subject PET images were compared using the Alzheimer's discrimination analysis by dedicated software. Forty-two PET/CT scans were used in the study. They were performed on eleven ADNI subjects at intervals of approximately 6 months. The final clinical diagnosis was used as a gold standard. For three subjects, the final clinical diagnosis was mild cognitive impairment and those 13 PET/CT studies were not included in the final comparison, as the result was considered as inconclusive. Using the reminding 29 PET/CT studies (23 AD and 6 normal), the sensitivity and specificity of the PET-O and PET-R were calculated. The sensitivity was 0.65 and 0.96 for PET-O and PET-R, respectively, and the specificity was 0.67 and 0.50 for PET-O and PET-R. The accuracy was 0.66 and 0.86 for PET-O and PET-R, respectively. The results of the study demonstrated that the accuracy of three-dimensional brain F-18 FDG PET images was significantly improved by Fourier-wavelet restoration filtering.
目标是通过应用一种新型的混合傅里叶 - 小波加窗傅里叶变换（WFT）恢复技术来改善阿尔茨海默病的2 - 脱氧 - 2 - （18）F - 氟 - D - 葡萄糖（（18）F FDG） - 正电子发射断层扫描（PET）/计算机断层扫描（CT）成像，以便提供更早且更准确的临床结果。使用通用电气医疗系统的下视声纳PET/CT 16层系统进行研究。根据阿尔茨海默病神经影像学倡议（ADNI）方案获取患者数据。在此，我们实施了傅里叶 - 小波正则化恢复，采用巴特沃斯低通滤波器，阶数n = 6，截止频率f = 0.35周期/像素，并进行小波（Daubechies，阶数2）噪声抑制。使用专用软件通过阿尔茨海默病判别分析比较原始（PET - O）和恢复后的（PET - R）ADNI受试者PET图像。该研究使用了42次PET/CT扫描。它们是对11名ADNI受试者每隔约6个月进行一次。最终临床诊断用作金标准。对于三名受试者，最终临床诊断为轻度认知障碍，这13次PET/CT研究未纳入最终比较，因为结果被认为是不确定的。使用其余29次PET/CT研究（23例阿尔茨海默病患者和6例正常受试者），计算PET - O和PET - R的敏感性和特异性。PET - O的敏感性分别为0.65和0.96，PET - R的敏感性分别为0.67和0.50。PET - O和PET - R的准确性分别为0.66和0.86。研究结果表明，通过傅里叶 - 小波恢复滤波，三维脑F - 18 FDG PET图像的准确性得到了显著提高。
