J-ADNI PET core.
Ann Nucl Med. 2013 Jun;27(5):452-9. doi: 10.1007/s12149-013-0704-x. Epub 2013 Mar 13.
To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD).
Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal control subjects were recruited in the Japanese Alzheimer's disease neuroimaging initiative and examined with a PET scan during the 30-60 min after FDG injection. Three independent blinded experts interpreted the 30- to 60-min sum images, and images of patients with AD and MCI presenting AD patterns and normal subjects presenting normal patterns were used in the analysis. Early-scan (ES) and late-scan (LS) images were obtained from the data acquired at 30-35 min and 55-60 min after the injection, respectively. Separate target regions of interest (ROI) for ES and LS were defined as areas of significant reductions in the posterior cingulate and parietotemporal lobe in both hemispheres from the results of an initial cohort with 21 patients (AD 16, MCI 5) and 19 controls. A subsequent sample of 36 (AD 9, MCI 27) patients and 38 controls were used to compare the diagnostic capability of ES and LS using Z scores within the target ROI in individual statistical parametric mapping analysis.
Compared to LS, ES showed lower activity in the frontal lobes and higher activity in the venous sinus than LS; however, the diagnostic capability of ES and LS did not significantly differ (sensitivity 0.97 and 0.97, specificity 0.82 and 0.84, area under the receiver-operating characteristic curve 0.96 and 0.97, respectively).
For a qualitative diagnosis of the AD pattern in 3D FDG-PET, results of ES were equivalent to those of LS. ES may be an option to shorten the entire PET procedure time, particularly in diagnosing early stages of AD.
确定三维正电子发射断层扫描（3D-PET）与（18）F-2-氟-2-脱氧-D-葡萄糖（（18）F-FDG）的最佳采集时间，以检测出典型的阿尔茨海默病（AD）脑摄取模式。
日本阿尔茨海默病神经影像学倡议招募了轻度 AD 或遗忘型轻度认知障碍（MCI）患者和正常对照者，并在注射 FDG 后 30-60 分钟内进行 PET 扫描。三位独立的、盲法的专家对 30-60 分钟总和图像进行了解读，使用 AD 模式的 AD 患者和 MCI 患者以及正常模式的正常对照者的图像进行了分析。早期扫描（ES）和晚期扫描（LS）图像分别来自注射后 30-35 分钟和 55-60 分钟采集的数据。分别为双侧后扣带回和顶颞叶区域的显著减少，定义为 ES 和 LS 的目标感兴趣区（ROI）。通过对 21 例患者（AD16 例，MCI5 例）和 19 例对照者的初始队列的结果，定义了 ES 和 LS 的单独目标 ROI；随后，使用个体统计参数映射分析中目标 ROI 内的 Z 分数，对 36 例（AD9 例，MCI27 例）患者和 38 例对照者的 ES 和 LS 的诊断能力进行了比较。
与 LS 相比，ES 显示额叶活动降低，静脉窦活动升高，但 ES 和 LS 的诊断能力无显著差异（敏感性 0.97 和 0.97，特异性 0.82 和 0.84，ROC 曲线下面积 0.96 和 0.97）。
对于 3D FDG-PET 的 AD 模式定性诊断，ES 的结果与 LS 相当。ES 可能是缩短整个 PET 程序时间的一种选择，特别是在诊断 AD 的早期阶段。
