Ahmed Abdel Rahman Sherine Hosny, Hussein Mohamed Saber, Mansour Amira Ibrahim
Drs. Ahmed, Hussein, and Mansour are with the Faculty of Medicine, Benha University in Banha, Egypt.
J Clin Aesthet Dermatol. 2019 Nov;12(11):28-31. Epub 2019 Nov 1.
Vitiligo is a multifactorial polygenic disorder commonly associated with other autoimmune diseases. The reported link between vitiligo and abnormalities of serum interleukin (IL)-17, zinc, calcium, and vitamin D is not fully understood. We sought to assess the serum levels of vitamin D, calcium, zinc, and IL-17 in patients with vitiligo and to answer the question of whether patients with vitiligo are more prone to experience myocardial infarction. This was a case-control study and we did not exclude any eligible participants with other systemic autoimmune diseases. Serum vitamin D, calcium, zinc, and IL-17 levels were measured and correlated with disease severity. The study was conducted at Benha University Hospital in Egypt. Thirty patients with vitiligo and 30 age- and sex-matched healthy volunteers were included. Disease severity was measured using the Vitiligo Extent Tensity Index (VETI) score. Patients with vitiligo showed significantly lower levels of vitamin D (<0.001), calcium (<0.001), and zinc (<0.001), and an insignificantly higher level of IL-17 compared to the control group (=0.102). Patients with other autoimmune diseases showed significantly lower vitamin D (=0.0001) and calcium (<0.0001) levels and higher IL-17 (=0.0431) and zinc (=0.0274) compared to controls. The levels of measured markers might make patients with vitiligo, especially those with autoimmune diseases, prone to myocardial infarction; the investigation of myocardial infarction, especially when a patient shows low vitamin D, calcium, and zinc or high IL-17 are recommended.
白癜风是一种多因素的多基因疾病，通常与其他自身免疫性疾病相关。白癜风与血清白细胞介素（IL）-17、锌、钙和维生素D异常之间的报道联系尚未完全明确。我们旨在评估白癜风患者血清中维生素D、钙、锌和IL-17的水平，并回答白癜风患者是否更容易发生心肌梗死的问题。这是一项病例对照研究，我们没有排除任何患有其他系统性自身免疫性疾病的合格参与者。测量血清维生素D、钙、锌和IL-17水平，并将其与疾病严重程度相关联。该研究在埃及本哈大学医院进行。纳入了30例白癜风患者和30名年龄及性别匹配的健康志愿者。使用白癜风范围强度指数（VETI）评分来衡量疾病严重程度。与对照组相比，白癜风患者的维生素D（<0.001）、钙（<0.001）和锌（<0.001）水平显著降低，而IL-17水平略高（=0.102）。与对照组相比，患有其他自身免疫性疾病的患者维生素D（=0.0001）和钙（<0.0001）水平显著降低，IL-17（=0.0431）和锌（=0.0274）水平升高。所测量标志物的水平可能使白癜风患者，尤其是那些患有自身免疫性疾病的患者，更容易发生心肌梗死；建议对心肌梗死进行调查，特别是当患者维生素D、钙和锌水平低或IL-17水平高时。
