Turk J Med Sci. 2015;45(4):940-6. doi: 10.3906/sag-1409-77.
BACKGROUND/AIM: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes.
H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients.
The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectivel cagA was more prevalent in Indians (39.7%), babA2 was more prevalent in Malays (39.5%), and dupA detection occurred more frequently in both Indians and Malays and at the same rate (37.5%). The Chinese inhabitants had the lowest prevalence of the three genes. Nonulcer disease patients had a significantly higher distribution of cagA (76.7%), babA2 (74.4%), and dupA (75.0%). There was no apparent association between these virulence genes and the clinical outcomes.
The lower prevalence of these genes and variations among different ethnicities implies that the strains are geographically and ethnically dependent. None of the virulence genes were knowingly beneficial in predicting the clinical outcome of H. pylori infection in our subjects.
背景/目的：消化不良疾病的严重程度归因于幽门螺杆菌的毒力基因。本研究的目的是确定幽门螺杆菌毒力基因（cagA、babA2 和 dupA）的分布，并确定其与临床消化不良结局之间是否存在显著相关性。
通过聚合酶链反应从 105 例幽门螺杆菌阳性患者的胃活检样本中鉴定幽门螺杆菌基因型 cagA、babA2 和 dupA。
幽门螺杆菌消化不良患者 cagA、babA2 和 dupA 基因的阳性率分别为 69.5%、41.0%和 22.9%，cagA 在印度人中更为常见（39.7%），babA2 在马来人中更为常见（39.5%），dupA 在印度人和马来人中的检出率均较高（37.5%）。中国居民这三种基因的患病率最低。非溃疡性疾病患者 cagA（76.7%）、babA2（74.4%）和 dupA（75.0%）的分布显著较高。这些毒力基因与临床结局之间似乎没有明显的关联。
这些基因的低流行率和不同种族之间的差异表明，这些菌株具有地域和种族依赖性。在我们的研究对象中，这些毒力基因均无法用于预测幽门螺杆菌感染的临床结局。
