Bredenkamp J K, Zimmerman M C, Mickel R A
Division of Head and Neck Surgery, UCLA School of Medicine.
Arch Otolaryngol Head Neck Surg. 1989 Jan;115(1):99-104. doi: 10.1001/archotol.1989.01860250101036.
Ameloblastomas are benign tumors derived from the odontogenic apparatus. Of these tumors, 80% originate in the mandible, while 20% originate in the maxilla. Six cases of maxillary ameloblastoma treated at the UCLA hospitals are presented; four of these cases showed extensive and destructive tumor growth involving vital structures, including the orbit, base of skull, and parasellar structures. Two of four patients with extensive disease died of their tumors, one, with extensive involvement of the base of the skull, became unavailable for follow-up, and, one year after diagnosis, one is alive with middle cranial fossa disease. A review of the medical literature provides further evidence of the locally aggressive behavior and potentially lethal nature of this tumor. No effective treatment has evolved for extensive ameloblastomas of the maxilla that have invaded surrounding vital structures. When tumor-free surgical margins are not possible, radiation therapy may offer palliation of disease.
成釉细胞瘤是源自牙源性器官的良性肿瘤。在这些肿瘤中，80%起源于下颌骨，20%起源于上颌骨。本文介绍了加利福尼亚大学洛杉矶分校医院治疗的6例上颌成釉细胞瘤；其中4例显示肿瘤广泛且具有破坏性生长，累及重要结构，包括眼眶、颅底和鞍旁结构。4例患有广泛性疾病的患者中有2例死于肿瘤，1例因颅底广泛受累而失访，诊断1年后，1例患有中颅窝疾病的患者仍存活。医学文献回顾进一步证明了该肿瘤的局部侵袭性和潜在致死性。对于侵犯周围重要结构的广泛性上颌成釉细胞瘤，尚未出现有效的治疗方法。当无法获得无瘤手术切缘时，放射治疗可能会缓解疾病。
