HIV-1 结核病相关免疫重建炎症综合征
HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome.
作者信息
Lai Rachel P J, Meintjes Graeme, Wilkinson Robert J
机构信息
The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK.
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Room 3.03.05, Wolfson Pavilion, Anzio Road, Observatory, Cape Town, 7925, South Africa.
出版信息
Semin Immunopathol. 2016 Mar;38(2):185-98. doi: 10.1007/s00281-015-0532-2. Epub 2015 Sep 30.
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
同时感染人类免疫缺陷病毒1型（HIV-1）和结核病（TB）的患者在开始抗逆转录病毒治疗（ART）后有发生结核病相关免疫重建炎症综合征（TB-IRIS）的风险。TB-IRIS的特征是针对结核分枝杆菌抗原出现短暂但严重的局部或全身炎症反应。在此，我们综述了TB-IRIS的危险因素和临床管理，以及免疫反应的不同方面在TB-IRIS发病机制中所起的作用。
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