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耐多药结核性腹膜炎:一例报告

Multi-Drug-Resistant Tuberculosis Peritonitis: A Case Report.

作者信息

Verma Rhea, Sonier Clinton, Rizvi Nida, Kashyap Rahul

机构信息

Medicine, Drexel University College of Medicine, Philadelphia, USA.

Internal Medicine, WellSpan Health, York, USA.

出版信息

Cureus. 2024 Feb 10;16(2):e53975. doi: 10.7759/cureus.53975. eCollection 2024 Feb.

Abstract

The increasing incidence of tuberculosis raises concerns globally, impacting both developing and developed nations. Abdominal tuberculosis stands out as the most prevalent form of extrapulmonary tuberculosis. This case report details the diagnostic journey of a young male with abdominal TB complicated by concurrent HIV infection. The patient presented with night sweats and substantial weight loss, concurrently receiving a naive human immunodeficiency virus (HIV) diagnosis with an undetectable CD4 count. Imaging revealed abdominal lymphadenopathy concealing the pancreatic head while bronchoscopy unveiled TB in the lung. The patient faced septic shock and bilateral pulmonary embolism, possibly due to immune reconstitution inflammatory syndrome (IRIS). The patient then developed ascites, and a diagnosis of TB peritonitis was made based on low serum ascites albumin gradient (SAAG) and a positive acid-fast bacillus (AFB) result in the para-aortic lymph node. Treatment complexity arose from drug resistance to isoniazid and ethambutol.

摘要

结核病发病率的不断上升引起了全球关注,对发展中国家和发达国家都产生了影响。腹部结核是肺外结核最常见的形式。本病例报告详细介绍了一名并发HIV感染的腹部结核年轻男性患者的诊断过程。患者出现盗汗和显著体重减轻,同时初次诊断为人类免疫缺陷病毒(HIV)感染,CD4细胞计数检测不到。影像学检查显示腹部淋巴结肿大掩盖了胰头,而支气管镜检查发现肺部有结核。患者面临感染性休克和双侧肺栓塞,可能是由于免疫重建炎症综合征(IRIS)。患者随后出现腹水,根据血清腹水白蛋白梯度(SAAG)低和主动脉旁淋巴结抗酸杆菌(AFB)检测结果阳性,诊断为结核性腹膜炎。由于对异烟肼和乙胺丁醇耐药,治疗变得复杂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3a9/10927249/61752daf51fe/cureus-0016-00000053975-i01.jpg

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