Yang H K, Han K, Park Y-M, Kwon H-S, Yoon K-H, Lee S-H
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Hum Hypertens. 2016 Oct;30(10):591-8. doi: 10.1038/jhh.2015.102. Epub 2015 Oct 1.
We aimed to investigate whether the effect of problematic alcohol drinking on hypertension differed according to metabolic health statuses. Male participants from the fifth Korea National Health and Nutrition Examination Survey were recruited. Problematic alcohol drinkers were designated as subjects with heavy drinking (⩾30 g per day), binge drinking (⩾7 glasses per day) or a high alcohol use disorders identification test score (⩾20). Metabolically obese status was defined as having ⩾1 or ⩾2 components of the diagnostic criteria for metabolic syndrome, excluding the blood pressure component. Because the prevalence of problematic alcohol drinking and the prevalence of hypertension largely differed by age groups, separate analyses were performed for the two age groups (<50 and ⩾50 years). Among a total of 6329 subjects, 37.04% had hypertension. In the younger age group, subjects with problematic alcohol drinking demonstrated a higher prevalence of hypertension in both nonobese and obese individuals compared with subjects who were nonobese and who were not problematic alcohol drinkers. Of note, problematic alcohol drinking increased the risk of having hypertension ∼3 times in young nonobese individuals who demonstrated a metabolically obese phenotype compared with those who were metabolically healthy. However, metabolic health status did not have a significant impact on the risk for having hypertension in obese participants, regardless of their age groups. For the prevention of hypertension, avoidance of problematic alcohol drinking should be emphasized, especially in young subjects who show poor metabolic health status despite being nonobese.
我们旨在研究有问题的饮酒对高血压的影响是否因代谢健康状况而异。招募了韩国第五次全国健康与营养检查调查中的男性参与者。有问题的饮酒者被定义为重度饮酒者（每天⩾30克）、暴饮者（每天⩾7杯）或酒精使用障碍识别测试得分较高者（⩾20）。代谢性肥胖状态被定义为具有代谢综合征诊断标准中的⩾1项或⩾2项指标，不包括血压指标。由于有问题的饮酒患病率和高血压患病率在不同年龄组中差异很大，因此对两个年龄组（<50岁和⩾50岁）分别进行了分析。在总共6329名受试者中，37.04%患有高血压。在较年轻的年龄组中，与非肥胖且无问题饮酒的受试者相比，有问题饮酒的受试者在非肥胖和肥胖个体中高血压患病率均较高。值得注意的是，与代谢健康的年轻非肥胖个体相比，有问题的饮酒使具有代谢性肥胖表型的年轻非肥胖个体患高血压的风险增加了约3倍。然而，无论年龄组如何，代谢健康状况对肥胖参与者患高血压的风险均无显著影响。为预防高血压，应强调避免有问题的饮酒，尤其是在尽管非肥胖但代谢健康状况较差的年轻受试者中。
