Ezzati Ali, Katz Mindy J, Lipton Michael L, Zimmerman Molly E, Lipton Richard B
Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Rousso Bldg. Rm. 330, Bronx, NY, 10461, USA.
Department of Neurology, Montefiore Medical Center, Bronx, NY, 10467, USA.
Brain Imaging Behav. 2016 Sep;10(3):652-9. doi: 10.1007/s11682-015-9452-y.
The objective of this study was to investigate the relationship of medial temporal lobe and posterior cingulate cortex (PCC) volumetrics as well as fractional anisotropy of the cingulum angular bundle (CAB) and the cingulum cingulate gyrus (CCG) bundle to performance on measures of verbal memory in non-demented older adults. The participants were 100 non-demented adults over the age of 70 years from the Einstein Aging Study. Volumetric data were estimated from T1-weighted images. The entire cingulum was reconstructed using diffusion tensor MRI and probabilistic tractography. Association between verbal episodic memory and MRI measures including volume of hippocampus (HIP), entorhinal cortex (ERC), PCC and fractional anisotropy of CAB and CCG bundle were modeled using linear regression. Relationships between atrophy of these structures and regional cingulum fractional anisotropy were also explored. Decreased HIP volume on the left and decreased fractional anisotropy of left CAB were associated with lower memory performance. Volume changes in ERC, PCC and CCG disruption were not associated with memory performance. In regression models, left HIP volume and left CAB-FA were each independently associated with episodic memory. The results suggest that microstructural changes in the left CAB and decreased left HIP volume independently influence episodic memory performance in older adults without dementia. The importance of these findings in age and illness-related memory decline require additional exploration.
本研究的目的是调查内侧颞叶和后扣带回皮质（PCC）的体积测量值，以及扣带角束（CAB）和扣带扣带回束（CCG）的分数各向异性与非痴呆老年人言语记忆测量指标表现之间的关系。研究参与者为来自爱因斯坦衰老研究的100名70岁以上的非痴呆成年人。从T1加权图像估计体积数据。使用扩散张量MRI和概率性纤维束成像重建整个扣带。使用线性回归对言语情景记忆与MRI测量指标之间的关联进行建模，这些指标包括海马体（HIP）、内嗅皮质（ERC）、PCC的体积以及CAB和CCG束的分数各向异性。还探讨了这些结构的萎缩与区域扣带分数各向异性之间的关系。左侧HIP体积减小和左侧CAB分数各向异性降低与较低的记忆表现相关。ERC、PCC和CCG束破坏的体积变化与记忆表现无关。在回归模型中，左侧HIP体积和左侧CAB-FA各自独立地与情景记忆相关。结果表明，左侧CAB的微观结构变化和左侧HIP体积减小独立影响无痴呆老年人的情景记忆表现。这些发现在与年龄和疾病相关的记忆衰退中的重要性需要进一步探索。
