Department of Surgery, St. John of God Hospital Regensburg, Regensburg, Germany
Department of Surgery, St. John of God Hospital Regensburg, Regensburg, Germany.
Gastroenterol Rep (Oxf). 2015 Nov;3(4):298-302. doi: 10.1093/gastro/gov044. Epub 2015 Sep 30.
Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis (after the liver). In the era of 5-fluorouracil (5-FU)-only chemotherapy, the prognosis was poor for colorectal cancer with peritoneal metastases. Within the last few years, new chemotherapeutic and targeted agents have improved the prognosis; however, the response to these treatments seems to be lower than that for liver metastases. The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have further improved both disease-free survival and overall survival. Keeping this in mind, every patient presenting with peritoneal metastases from colorectal cancer should be evaluated and receive adequate treatment, if possible in the above-mentioned combination. This paper reviews recent advancements in the therapy of peritoneal carcinomatosis.
结直肠肿瘤的腹膜种植是仅次于肝脏的第二大转移部位。在仅使用氟尿嘧啶（5-FU）化疗的时代，结直肠伴有腹膜转移的预后较差。在过去几年中，新的化疗药物和靶向药物改善了预后；然而，这些治疗的反应似乎低于肝转移。细胞减灭术和腹腔热灌注化疗的联合应用进一步提高了无病生存率和总生存率。考虑到这一点，对于结直肠来源的腹膜转移患者，应进行评估并给予适当的治疗，如果可能的话，应采用上述联合治疗。本文综述了腹膜癌病治疗的最新进展。
