Saluja Rohit, Khan Mahejibin, Church Martin K, Maurer Marcus
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany ; Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh 462024 India ; Ramalingaswami Fellow, Department of Biotechnology, Government of India, New Delhi, India.
Central Food Technological Research Institute-Resource Centre, Lucknow, India.
Clin Transl Allergy. 2015 Sep 29;5:33. doi: 10.1186/s13601-015-0076-5. eCollection 2015.
Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and smooth muscle cells. During necrosis of these cells (after tissue injury or cell damage), the IL-33 that is released may be recognized by different types of immune cells, such as eosinophils, basophils and, especially, mast cells. IL-33 needs the specific receptor ST2 (membrane-bound receptor) and Interleukin-1 receptor accessory protein heterodimer for its binding, which instigates the production of different types of cytokines and chemokines that have crucial roles in the exacerbation of allergic diseases and inflammation. IL-33 and mast cells have been influentially associated to the pathophysiology of allergic diseases and inflammation. IL-33 is a crucial regulator of mast cell functions and might be an attractive therapeutic target for the treatment of allergic and inflammatory diseases. In this review, we summarize the current knowledge regarding the roles of IL-33 and mast cells in the pathogenesis of allergies and inflammation.
白细胞介素-33（IL-33）是白细胞介素-1（IL-1）细胞因子家族的成员。它在不同的结构细胞如上皮细胞、内皮细胞和平滑肌细胞中优先且组成性地表达。在这些细胞坏死期间（组织损伤或细胞损伤后），释放的IL-33可能被不同类型的免疫细胞识别，如嗜酸性粒细胞、嗜碱性粒细胞，尤其是肥大细胞。IL-33需要特异性受体ST2（膜结合受体）和白细胞介素-1受体辅助蛋白异二聚体来进行结合，这会促使产生不同类型的细胞因子和趋化因子，它们在过敏性疾病和炎症的加剧过程中发挥关键作用。IL-33和肥大细胞与过敏性疾病和炎症的病理生理学密切相关。IL-33是肥大细胞功能的关键调节因子，可能是治疗过敏性和炎症性疾病的一个有吸引力的治疗靶点。在本综述中，我们总结了关于IL-33和肥大细胞在过敏和炎症发病机制中作用的当前知识。
