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J Allergy Clin Immunol. 2014 Aug;134(2):420-8. doi: 10.1016/j.jaci.2014.01.037. Epub 2014 Mar 26.
2
Survival improvement by decade of patients aged 0-14 years with acute lymphoblastic leukemia: a SEER analysis.0至14岁急性淋巴细胞白血病患者按十年划分的生存改善情况：一项监测、流行病学和最终结果（SEER）分析
Sci Rep. 2014 Feb 27;4:4227. doi: 10.1038/srep04227.
3
Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.FTY720 在费城阳性和阴性 B 细胞系急性淋巴细胞白血病异种移植模型中的体内疗效差异。
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Autophagy. 2011 Jul;7(7):707-15. doi: 10.4161/auto.7.7.15154. Epub 2011 Jul 1.
6
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.一项口服芬戈莫德治疗复发性多发性硬化的安慰剂对照试验。
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8
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Blood. 2008 Jan 1;111(1):275-84. doi: 10.1182/blood-2006-10-053884. Epub 2007 Aug 29.
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J Clin Invest. 2007 Sep;117(9):2408-21. doi: 10.1172/JCI31095.

一名接受芬戈莫德治疗复发型多发性硬化症的男性患急性淋巴细胞白血病

Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis.

作者信息

Cohan Stanley, Godwin John, Gaedeke Leah

机构信息

Providence Health & Services, Portland, OR, USA.

出版信息

J Investig Med High Impact Case Rep. 2015 Mar 9;3(1):2324709615575551. doi: 10.1177/2324709615575551. eCollection 2015 Jan-Mar.

DOI:10.1177/2324709615575551
PMID:26425635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4586908/
Abstract

A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia reported in a patient treated with fingolimod. Although no causal relationship can be established between fingolimod use and acute lymphoblastic leukemia risk in this single case, future surveillance for lymphatic cell malignancies in patients treated with fingolimod appears justified.

摘要

一名复发型多发性硬化症男性患者，接受每日0.5毫克芬戈莫德治疗15个月后，患上急性淋巴细胞白血病，并在免疫消融和骨髓同种异体移植后4个月死于移植物抗宿主病。据我们所知，这是首例接受芬戈莫德治疗的患者发生急性淋巴细胞白血病的病例报告。尽管在这一单个病例中无法确定使用芬戈莫德与急性淋巴细胞白血病风险之间存在因果关系，但对接受芬戈莫德治疗的患者进行未来淋巴细胞恶性肿瘤监测似乎是合理的。