Center for Clinical Molecular Medicine, Children's Hospital, Key Laboratory of Developmental Disease in the Ministry of Education, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing Medical University, Chongqing, 400014, China.
Department of Blood Transfusion, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Int J Hematol. 2011 Apr;93(4):494-501. doi: 10.1007/s12185-011-0824-9. Epub 2011 Apr 12.
Acute lymphoblastic leukemia (ALL) is the main subtype of childhood leukemia. Risk stratification is pivotal for ALL prognosis and individualized therapy. The current factors for risk stratification include clinical and laboratory features, cytogenetic characteristics of the blast, early response to chemotherapy, and genetic factors. Analyses of gene expression are becoming increasingly important in ALL risk stratification. β-Arrestin1, a multifunctional scaffold protein mediating many intracellular signaling networks, has been shown to be involved in many tumors. However, little is known of β-arrestin1 in leukemia. In this study, we found that β-arrestin1 was significantly elevated in 155 newly diagnosed ALL patients, compared with 51 controls. Further analysis showed that β-arrestin1 expression was positively related with risk classification and white blood cell count in ALL. Moreover, expression of Notch1, an essential gene for developing hematological cells and T-ALL, was found to be negatively correlated with β-arrestin1 in ALL. In conclusion, β-arrestin1 may be a useful predictor of risk stratification and prognosis of ALL, and thus of potential use in the design of individualized therapy strategies.
急性淋巴细胞白血病 (ALL) 是儿童白血病的主要亚型。风险分层对 ALL 的预后和个体化治疗至关重要。目前的风险分层因素包括临床和实验室特征、白血病细胞的细胞遗传学特征、化疗早期反应和遗传因素。基因表达分析在 ALL 风险分层中的作用越来越重要。β-arrestin1 是一种多功能支架蛋白，介导许多细胞内信号网络，已被证明与许多肿瘤有关。然而，关于白血病中的β-arrestin1知之甚少。在这项研究中，我们发现与 51 名对照相比，在 155 名新诊断的 ALL 患者中，β-arrestin1 的表达明显升高。进一步分析表明，β-arrestin1 的表达与 ALL 中的风险分类和白细胞计数呈正相关。此外，在 ALL 中，发育血细胞和 T-ALL 的必需基因 Notch1 的表达与β-arrestin1 呈负相关。总之，β-arrestin1 可能是 ALL 风险分层和预后的有用预测指标，因此可能有助于设计个体化治疗策略。
