Tsutsu N, Takata Y, Nunoi K, Kikuchi M, Takishita S, Sadoshima S, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Metabolism. 1989 Jan;38(1):63-6. doi: 10.1016/0026-0495(89)90181-9.
We compared the glucose tolerance and insulin responses to intravenous (IV) glucose administration of a dose of 1 g/kg body weight in a conscious and unrestrained state of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) with catheters chronically indwelled into artery and vein. Both plasma glucose levels at two minutes and ten minutes following IV glucose load as well as the incremental and total areas of plasma glucose were slightly but significantly lower in SHR than in WKY. Glucose disappearance rate (K value) was 7.7 +/- 0.3%/min in SHR, being slightly but significantly higher than that of 6.8 +/- 0.3%/min in WKY. On the other hand, insulin responses to the glucose load at ten minutes and 30 minutes as well as incremental and total insulin areas were significantly lower in SHR than in WKY. There was no significant difference in insulinogenic index between SHR and WKY. Our observations suggest that in a conscious and unrestrained state, SHR have the greater glucose tolerance associated with reduced insulin secretion than do WKY.
我们比较了清醒且不受限制状态下的自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto大鼠（WKY）对静脉注射（IV）1 g/kg体重葡萄糖的糖耐量和胰岛素反应，这两种大鼠的动脉和静脉均长期留置导管。静脉注射葡萄糖负荷后两分钟和十分钟时的血浆葡萄糖水平以及血浆葡萄糖的增量和总面积，SHR均略低于WKY，但差异有统计学意义。SHR的葡萄糖消失率（K值）为7.7±0.3%/分钟，略高于WKY的6.8±0.3%/分钟，差异有统计学意义。另一方面，SHR在十分钟和三十分钟时对葡萄糖负荷的胰岛素反应以及胰岛素增量和总量均显著低于WKY。SHR和WKY之间的胰岛素生成指数无显著差异。我们的观察结果表明，在清醒且不受限制的状态下，SHR比WKY具有更高的糖耐量，且胰岛素分泌减少。
