Schultze Joachim L
Genomics & Immunoregulation, LIMES-Institute, University of Bonn, Carl-Troll-Str. 31, D-53115 Bonn, Germany.
Curr Opin Pharmacol. 2016 Feb;26:10-5. doi: 10.1016/j.coph.2015.09.007. Epub 2015 Sep 29.
Macrophages are key players of tissue homeostasis and are cells involved in all major human diseases including infections, tumors, western life-style associated diseases and even neurodegenerative diseases. Therefore, specifically targeting macrophages seems to be an attractive therapeutic approach, yet such strategies have not been successfully translated to the clinic. An important hallmark of macrophages is their astounding plasticity and their capacity to integrate microenvironmental signals to perform distinct biological functions. Understanding the cellular programming of macrophages during such events will be a fundamental pre-requisite to develop targeted therapeutic approaches in human diseases. Here, I highlight recent findings of how macrophage activation is regulated and how one can envision much more specific approaches of targeting macrophages.
巨噬细胞是组织稳态的关键参与者，并且涉及包括感染、肿瘤、西方生活方式相关疾病甚至神经退行性疾病在内的所有主要人类疾病。因此，特异性靶向巨噬细胞似乎是一种有吸引力的治疗方法，然而这些策略尚未成功转化应用于临床。巨噬细胞的一个重要特征是其惊人的可塑性以及整合微环境信号以执行不同生物学功能的能力。了解此类事件中巨噬细胞的细胞编程将是开发针对人类疾病的靶向治疗方法的基本先决条件。在此，我重点介绍了有关巨噬细胞激活如何受到调控以及如何设想出更具特异性的巨噬细胞靶向方法的最新研究发现。
