Ahmar Rauf Mohd, Nisar Maryam, Abdelhady Hosam, Gavande Navnath, Iyer Arun K
Department of Surgery, Miller School of Medicine, Sylvester Comprehensive Cancer Centre, University of Miami, FL 33136, USA; Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA.
Department of Biochemistry, Aligarh Muslim University, Aligarh, UP 202002, India.
Drug Discov Today. 2022 Nov;27(11):103355. doi: 10.1016/j.drudis.2022.103355. Epub 2022 Sep 12.
During a cytokine storm, dysregulated proinflammatory cytokines are produced in excess. Cytokine storms occur in multiple infectious diseases, including Coronavirus 2019 (COVID-19). Thus, eliminating cytokine storms to enhance patient outcomes is crucial. Given the numerous cytokines involved, individual therapies might have little effect. Traditional cytokines might be less effective than medicines that target malfunctioning macrophages. Nanomedicine-based therapeutics reduce cytokine production in animal models of proinflammatory illnesses. The unique physicochemical features and controlled nano-bio interactions of nanotechnology show promise in healthcare and could be used to treat several stages of this virus-induced sickness, including cytokine storm mortality. Macrophage-oriented nanomedicines can minimize cytokine storms and associated harmful effects, enhancing patient outcomes. Here, we also discuss engineering possibilities for enhancing macrophage efficacy with nanodrug carriers.
在细胞因子风暴期间，促炎细胞因子失调并过量产生。细胞因子风暴发生在多种传染病中，包括2019冠状病毒病（COVID-19）。因此，消除细胞因子风暴以改善患者预后至关重要。鉴于涉及众多细胞因子，单一疗法可能收效甚微。传统的细胞因子疗法可能不如针对功能失调巨噬细胞的药物有效。基于纳米医学的疗法可减少促炎疾病动物模型中的细胞因子产生。纳米技术独特的物理化学特性和可控的纳米-生物相互作用在医疗保健领域显示出前景，可用于治疗这种病毒引起疾病的多个阶段，包括细胞因子风暴导致的死亡。面向巨噬细胞的纳米药物可将细胞因子风暴及相关有害影响降至最低，改善患者预后。在此，我们还讨论了利用纳米药物载体提高巨噬细胞功效的工程可能性。
