Li Dongliang, Yang Xueying, Zhang Zheng, Wang Zixin, Qi Xiao, Ruan Yuhua, Zhou Yunhua, Li Chunrong, Luo Fengji, Lau Joseph T F
Chaoyang Center for Disease Control and Prevention, Beijing, PR China.
Center for Health Behaviours Research, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong SAR, Hong Kong, China.
PLoS One. 2016 Jan 28;11(1):e0147422. doi: 10.1371/journal.pone.0147422. eCollection 2016.
The HIV-epidemic among MSM in China has worsened. In this key population, prevalence of HSV-2 and syphilis infection and co-infection with HIV is high.
A longitudinal study was conducted (n = 962) in Beijing, China, with three overlapping cohorts (n = 857, 757 and 760) consisting of MSM that were free from pairs of infections of concern (i.e. HIV-HSV-2, HIV-syphilis, HSV-2-syphilis) at baseline to estimate incidence of HIV, HSV-2, syphilis, and those of co-infection.
The incidence of HIV, HSV-2 and syphilis in the overall cohort was 3.90 (95% CI = 2.37, 5.43), 7.87 (95% CI = 5.74, 10.00) and 6.06 (95% CI = 4.18, 7.94) cases per 100 person-years (PYs), respectively. The incidence of HIV-HSV-2, HIV-Syphilis and HSV-2-Syphilis co-infections was 0.30 (95% CI = 0.29, 0.88), 1.02 (95% CI = 0.13, 2.17) and 1.41 (95% CI: 0.04, 2.78) cases per 100 PYs, respectively, in the three sub-cohorts constructed for this study.
The incidence of HIV, HSV-2 and syphilis was very high and those of their co-infections were relatively high. Such co-infections have negative impacts on the HIV/STI epidemics. Prevention practices need to take such co-infections into account.
中国男男性行为者中的艾滋病疫情有所恶化。在这一关键人群中，单纯疱疹病毒2型（HSV-2）和梅毒感染以及与艾滋病病毒合并感染的患病率很高。
在中国北京进行了一项纵向研究（n = 962），有三个重叠队列（n = 857、757和760），由在基线时未感染所关注的成对感染（即艾滋病病毒-HSV-2、艾滋病病毒-梅毒、HSV-2-梅毒）的男男性行为者组成，以估计艾滋病病毒、HSV-2、梅毒以及合并感染的发病率。
整个队列中艾滋病病毒、HSV-2和梅毒的发病率分别为每100人年3.90例（95%置信区间 = 2.37，5.43）、7.87例（95%置信区间 = 5.74，10.00）和6.06例（95%置信区间 = 4.18，7.94）。在为本研究构建的三个亚组队列中，艾滋病病毒-HSV-2、艾滋病病毒-梅毒和HSV-2-梅毒合并感染的发病率分别为每100人年0.30例（95%置信区间 = 0.29，0.88）、1.02例（95%置信区间 = 0.13，2.17）和1.41例（95%置信区间：0.04，2.78）。
艾滋病病毒、HSV-2和梅毒的发病率非常高，它们的合并感染率也相对较高。这种合并感染对艾滋病/性传播感染疫情有负面影响。预防措施需要考虑到这种合并感染情况。
