Taubman B, Barroway R P, McGowan K L
Department of Pediatrics, Children's Hospital of Philadelphia.
Am J Dis Child. 1989 Jan;143(1):102-4. doi: 10.1001/archpedi.1989.02150130112027.
We compared a rapid latex agglutination test with cultures of throat specimens to diagnose group A beta-hemolytic streptococcal pharyngitis in an office setting. The throat cultures were interpreted by two pediatricians independently and evaluated by a reference laboratory. Five hundred seventy-two children participated in the study. The latex agglutination test had a sensitivity of 89.4% and a specificity of 85.7%. Cultures of throat specimens obtained in the office had a sensitivity of 91.9% and a specificity of 91.7% when interpreted by investigator 1, and a sensitivity of 90.0% and a specificity of 95.1% when interpreted by investigator 2. There was no statistically significant difference between the numbers of false-negative results generated by the two procedures. We conclude that although somewhat less specific, the latex test is as sensitive as cultures of throat specimens in the office setting.
我们在门诊环境中，将快速乳胶凝集试验与咽喉标本培养进行比较，以诊断A组β溶血性链球菌性咽炎。咽喉培养结果由两位儿科医生独立解读，并由一家参考实验室评估。572名儿童参与了这项研究。乳胶凝集试验的敏感性为89.4%，特异性为85.7%。门诊获取的咽喉标本培养，由研究者1解读时敏感性为91.9%，特异性为91.7%；由研究者2解读时敏感性为90.0%，特异性为95.1%。两种检测方法产生的假阴性结果数量之间无统计学显著差异。我们得出结论，虽然乳胶试验的特异性稍低，但在门诊环境中其敏感性与咽喉标本培养相同。
