Lieu T A, Fleisher G R, Schwartz J S
Pediatr Infect Dis. 1986 Nov-Dec;5(6):655-9. doi: 10.1097/00006454-198611000-00011.
Of 556 children with symptoms of streptococcal pharyngitis in a pediatric hospital emergency department, 38.8% had positive results on either a rapid latex agglutination test or throat culture for Group A Streptococcus. Twenty-six percent of patients with negative latex agglutination test results had growth on culture of a paired specimen. Under the best assumption rapid test sensitivity was 44.9%. The treatment rate (84%) for cases detected by the rapid test was markedly higher than the rate (44%) for cases detected only by culture (P less than 0.001), presumably because the rapid test result is available sooner. We conclude that: the rapid test had a lower sensitivity in routine use in our pediatric emergency department population than in previous reports from research settings; and using the rapid test in addition to culture can significantly increase treatment rates.
在一家儿科医院急诊科的556名有链球菌性咽炎症状的儿童中，38.8%的患儿A组链球菌快速乳胶凝集试验或咽拭子培养结果呈阳性。乳胶凝集试验结果为阴性的患者中，26%的配对标本培养有细菌生长。在最佳假设下，快速检测的敏感性为44.9%。快速检测检出病例的治疗率（84%）明显高于仅通过培养检出病例的治疗率（44%）（P<0.001），可能是因为快速检测结果能更快获得。我们得出结论：在我们儿科急诊科人群的常规使用中，快速检测的敏感性低于先前研究环境中的报告；除培养外使用快速检测可显著提高治疗率。
