神经免疫药理学方法。
Neuroimmune pharmacological approaches.
作者信息
Holzer Peter, Hassan Ahmed M, Jain Piyush, Reichmann Florian, Farzi Aitak
机构信息
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria.
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria.
出版信息
Curr Opin Pharmacol. 2015 Dec;25:13-22. doi: 10.1016/j.coph.2015.09.003. Epub 2015 Sep 29.
Abstract
Intestinal inflammation is a major health problem which impairs the quality of life, impacts mental health and is exacerbated by stress and psychiatric disturbances which, in turn, can affect disease prognosis and response to treatment. Accumulating evidence indicates that the immune system is an important interface between intestinal inflammation and the enteric, sensory, central and autonomic nervous systems. In addition, the neuroimmune interactions originating from the gastrointestinal tract are orchestrated by the gut microbiota. This article reviews some major insights into this complex homeostatic network that have been achieved during the past two years and attempts to put these advances into perspective with novel opportunities of pharmacological intervention.
摘要
肠道炎症是一个重大的健康问题，它会损害生活质量、影响心理健康，并且会因压力和精神障碍而加剧，而这些反过来又会影响疾病的预后和对治疗的反应。越来越多的证据表明，免疫系统是肠道炎症与肠道、感觉、中枢和自主神经系统之间的重要界面。此外，源自胃肠道的神经免疫相互作用是由肠道微生物群协调的。本文回顾了过去两年在这个复杂的稳态网络方面取得的一些主要见解，并试图结合药理学干预的新机会来审视这些进展。
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