Peat Christine M, Kleiman Susan C, Bulik Cynthia M, Carroll Ian M
Department of Psychiatry, University of North Carolina at Chapel Hill, USA.
Department of Nutrition, University of North Carolina at Chapel Hill, USA.
Eur Eat Disord Rev. 2015 Nov;23(6):496-503. doi: 10.1002/erv.2400. Epub 2015 Oct 1.
With nearly 39% of the worldwide adult population classified as obese, much of the globe is facing a serious public health challenge. Increasing rates of obesity, coupled with the failure of many behavioural and pharmacological interventions, have contributed to a rise in popularity of bariatric surgery as a treatment for obesity. Surgery-mediated weight loss was initially thought to be a direct result of mechanical alterations causing restriction and calorie malabsorption. However, the mounting evidence suggests that indirect factors influence the accumulation and storage of fat in patients that have undergone this procedure. Given the established impact the intestinal microbiota has on adiposity, it is likely that this complex enteric microbial community contributes to surgery-mediated weight loss and maintenance of weight loss postsurgery. In this review, we discuss the physiological and psychological traits exhibited by bariatric surgery candidates that can be influenced by the intestinal microbiota. Additionally, we detail the studies that investigated the impact of bariatric surgery on the intestinal microbiota in humans and mouse models of this procedure.
全球近39%的成年人口被归类为肥胖，世界上许多地区都面临着严峻的公共卫生挑战。肥胖率不断上升，再加上许多行为和药物干预措施效果不佳，使得减肥手术作为一种治疗肥胖的方法越来越受欢迎。手术介导的体重减轻最初被认为是机械改变导致限制和热量吸收不良的直接结果。然而，越来越多的证据表明，间接因素会影响接受过该手术的患者体内脂肪的积累和储存。鉴于肠道微生物群对肥胖已确定的影响，这个复杂的肠道微生物群落很可能有助于手术介导的体重减轻以及术后体重减轻的维持。在这篇综述中，我们讨论了减肥手术候选者表现出的可能受肠道微生物群影响的生理和心理特征。此外，我们详细介绍了在人类和该手术的小鼠模型中研究减肥手术对肠道微生物群影响的研究。
