Department of Food Science & Nutrition, College of Food Science & Agriculture, King Saud University, Riyadh 11495, Saudi Arabia.
Botany and Microbiology Department, Science College, Female Campus, King Saud University, Riyadh 11495, Saudi Arabia.
Nutrients. 2023 Jan 11;15(2):361. doi: 10.3390/nu15020361.
Obesity prevalence is rising globally, as are the number of chronic disorders connected with obesity, such as diabetes, non-alcoholic fatty liver disease, dyslipidemia, and hypertension. Bariatric surgery is also becoming more common, and it remains the most effective and long-term treatment for obesity. This study will assess the influence of Laparoscopic Sleeve Gastrectomy (LSG) on gut microbiota in people with obesity before and after surgery. The findings shed new light on the changes in gut microbiota in Saudi people with obesity following LSG. In conclusion, LSG may improve the metabolic profile, resulting in decreased fat mass and increased lean mass, as well as improving the microbial composition balance in the gastrointestinal tract, but this is still not equivalent to normal weight microbiology. A range of factors, including patient characteristics, geographic dispersion, type of operation, technique, and nutritional and caloric restriction, could explain differences in abundance between studies. This information could point to a novel and, most likely, tailored strategy in obesity therapy, which could eventually be incorporated into health evaluations and monitoring in preventive health care or clinical medicine.
肥胖症在全球范围内的患病率不断上升，与之相关的慢性疾病的数量也在增加，如糖尿病、非酒精性脂肪肝、血脂异常和高血压。减重手术也变得越来越普遍，并且仍然是肥胖症最有效和长期的治疗方法。本研究将评估腹腔镜袖状胃切除术（LSG）对肥胖症患者手术前后肠道微生物群的影响。研究结果为沙特肥胖症患者 LSG 后肠道微生物群的变化提供了新的视角。总之，LSG 可能会改善代谢状况，导致脂肪量减少和瘦体重增加，以及改善胃肠道微生物组成平衡，但这仍与正常体重微生物群不同。一系列因素，包括患者特征、地理分布、手术类型、技术以及营养和热量限制，可能可以解释不同研究之间丰度的差异。这些信息可能指向肥胖症治疗的一种新的、很可能是量身定制的策略，最终可能会被纳入预防性保健或临床医学中的健康评估和监测。
