Miller Iben M, Vindsand Naver Astrid, Mogensen Ulla B, Zarchi Kian, Ring Hans C, Ellervik Christina, Jemec Gregor B E
aDepartment of Dermatology, Roskilde Hospital, Roskilde bFaculty of Health and Medical Sciences cDepartment of Clinical Medicine, Faculty of Health and Medical Sciences dDepartment of Biostatistics, University of Copenhagen, Copenhagen eThe Gastro-Unit, Hvidovre Hospital, Hvidovre fThe General Population Study, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.
Eur J Gastroenterol Hepatol. 2015 Dec;27(12):1392-8. doi: 10.1097/MEG.0000000000000469.
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease that was recently linked to the metabolic syndrome (MetS). MetS has been associated with gallstones, and nonalcoholic fatty liver has been suggested to be the hepatic expression of MetS.
The objective of the study was to investigate whether there was an association of HS with gallstones as well as with hepatic dysfunction.
This was a cross-sectional study comparing a hospital-based HS group, a population-based HS group, and controls for self-reported gallstone and blood sample verified hepatic dysfunction. Blood samples were analyzed for alanine transaminase, bilirubin, alkaline phosphatase, albumin, thrombocytes, and the international normalized ratio.
A total of 32 hospital HS patients, 430 population-based HS patients, and 20 780 non-HS controls were identified. The age-sex-smoking-adjusted analysis of gallstones revealed a significant OR of 1.72 (95% CI 1.23-2.42, P=0.0191) and a borderline significant OR of 3.28 (95% CI 1.24-8.74, P=0.0516) for the population HS group and hospital HS group versus controls, respectively. Furthermore, no clinically significant evidence was found with regard to hepatic dysfunction.
This study demonstrates an association of HS with gallstones, but not with hepatic dysfunction. The association with gallstones may be partly explained by the comorbidity of hypertriglyceridemia and obesity as a part of MetS.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，最近被认为与代谢综合征（MetS）有关。MetS与胆结石有关，非酒精性脂肪性肝病被认为是MetS的肝脏表现形式。
本研究的目的是调查HS与胆结石以及肝功能障碍之间是否存在关联。
这是一项横断面研究，比较了以医院为基础的HS组、以人群为基础的HS组以及自我报告有胆结石和经血液样本验证有肝功能障碍的对照组。对血液样本进行丙氨酸转氨酶、胆红素、碱性磷酸酶、白蛋白、血小板和国际标准化比值的分析。
共确定了32例以医院为基础的HS患者、430例以人群为基础的HS患者和20780例非HS对照组。对胆结石进行年龄、性别、吸烟因素调整后的分析显示，与对照组相比，以人群为基础的HS组和以医院为基础的HS组的优势比分别为1.72（95%CI 1.23-2.42，P=0.0191）和临界显著的3.28（95%CI 1.24-8.74，P=0.0516）。此外，未发现关于肝功能障碍的临床显著证据。
本研究表明HS与胆结石有关，但与肝功能障碍无关。与胆结石的关联可能部分由作为MetS一部分的高甘油三酯血症和肥胖症的合并症来解释。
